The Factor V G1691A, Factor V H1299R, prothrombin G20210A polymorphisms in children with family history of premature coronary artery disease

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dc.contributor.authorÇiftdogan, DY
dc.contributor.authorCoskun, S
dc.contributor.authorUlman, C
dc.contributor.authorTikiz, H
dc.date.accessioned2024-07-18T11:49:01Z
dc.date.available2024-07-18T11:49:01Z
dc.description.abstractAtherosclerosis, the major cause of coronary artery disease (CAD), has a very long asymptomatic development phase, which begins in childhood. In this study, we describe the Factor V G1691A, Factor V H1299R and prothrombin G20210A gene polymorphisms in children with a family history of premature CAD. Evidence of these polymorphisms in these children may predict the probability of having atherosclerosis in the future. Our study included a total of 140 children, 72 males and 68 females between the ages of 4.9 and 15.7 years. Among these children, 73 had a parental history of premature CAD and the remaining 67 belonged to our control group. The participants were screened for the mutations Factor V G1691 A, Factor V H1299R and prothrombin G20210A by polymerase chain reaction amplified DNA products with specific oligonucleotide probes. Our results suggested that frequencies of the mutated allele of Factor V G1691A and prothrombin G20210A are higher in children with a parental history of premature CAD. In conclusion, Factor V G1691A and prothrombin G20210A polymorphisms which were detected in higher frequencies in children with a parental history of premature CAD may indicate a risk for developing atherosclerosis and might be useful in screening for CAD in children; however, large population-based research is necessary to investigate further genetic risk assessment for CAD. Coron Artery Dis 20:435-439 (C) 2009 Wolters Kluwar Health vertical bar Lippincott Williams & Wilkins.
dc.identifier.issn0954-6928
dc.identifier.other1473-5830
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/3678
dc.language.isoEnglish
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.subjectGENE POLYMORPHISMS
dc.subjectRISK-FACTORS
dc.subjectLEIDEN
dc.subjectATHEROSCLEROSIS
dc.subjectGENOTYPE
dc.subjectVARIANT
dc.titleThe Factor V G1691A, Factor V H1299R, prothrombin G20210A polymorphisms in children with family history of premature coronary artery disease
dc.typeArticle

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