ANTI-ACETYLCHOLINESTERASE, ANTIPROTOZOAL AND CYTOTOXIC ACTIVITIES OF SOME TURKISH MARINE ALGAE

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dc.contributor.authorCinar, E
dc.contributor.authorTaskin, E
dc.contributor.authorTasdemir, D
dc.contributor.authorOzkale, E
dc.contributor.authorGrienke, U
dc.contributor.authorFirsova, D
dc.date.accessioned2024-07-18T12:03:33Z
dc.date.available2024-07-18T12:03:33Z
dc.description.abstractThe crude (MeOH:CHCl3) and n-hexane-soluble extracts from four brown algae (Phaeophyceae) [Petalonia fascia, Cystoseira crinita, Cystoseira foeniculacea, and Halopteris scoparia], one red alga (Rhodophyta) [Jania rubens] and three green algae (Chlorophyta) [Chaetomorpha aerea, Codium fragile subsp. fragile, and Ulva compressa] from Turkish coasts (Izmir Bay, Ayvalik and canaldcale) were assessed in vitro for their acetylcholinesterase (AChE) inhibitory activities at 200, 150, 50, 20 mu g/mL test concentration with Ellman's method. The crude extract of P. fascia possessed the highest inhibition (IC50 value of 19,22 +/- 10,47 mu g/mL) against AChE. Galanthamine HBr was used as standard drug that gave against AChE enzyme IC50 of 3.44 +/- 1.14 mu M. In the second stage, the crude, hexane-soluble, chloroform-soluble and water-methanol soluble extracts of the marine algae were observed in vitro against parasitic protozoa (Plasmodium falciparum, Trypanosoma brucei brucei, Trypanosoma cruzi ye Leishmania infantum). According to results, the most potent protozoal activities were shown by the Khex of C. crinita (IC50 value of 10,62 mu g/ml), followed by the Khex of C. fragile subsp. fragile (IC50 value of 11,89 mu g/ml). The hekzan-soluble (Khex) and chloroform-soluble (KCH) extracts gave the best results. The marine algae were also tested on MRC-5 cells (human fibroblasts) for by controlling tamoxifen. The extracts of H. scoparia, C. aerea ye C. fragile subsp. fragile showed toxicity.
dc.identifier.issn1018-4619
dc.identifier.other1610-2304
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/9176
dc.language.isoEnglish
dc.publisherPARLAR SCIENTIFIC PUBLICATIONS (P S P)
dc.subjectACETYLCHOLINESTERASE INHIBITORY-ACTIVITY
dc.subjectIN-VITRO
dc.subjectBROWN ALGA
dc.subjectFRESH-WATER
dc.subjectSARGASSUM
dc.subjectPHLOROTANNINS
dc.subjectANTIOXIDANT
dc.subjectSEAWEEDS
dc.subjectANTIMYCOBACTERIAL
dc.subjectPOLYSACCHARIDES
dc.titleANTI-ACETYLCHOLINESTERASE, ANTIPROTOZOAL AND CYTOTOXIC ACTIVITIES OF SOME TURKISH MARINE ALGAE
dc.typeArticle

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