Does peri-implant bone loss affect the LL-37 and proteinase 3 levels in peri-implant sulcus fluid?

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dc.contributor.authorTurkoglu, O
dc.contributor.authorEfeoglu, C
dc.contributor.authorAtmaca, H
dc.date.accessioned2024-07-18T12:01:24Z
dc.date.available2024-07-18T12:01:24Z
dc.description.abstractBackground Inactive human cathelicidin antimicrobial peptide is present in neutrophils, and proteinase 3 activates this peptide by producing active LL-37 peptide. LL-37 acts as a defensive peptide in the oral tissues. In the present study, the aim was to evaluate LL-37 and proteinase 3 levels in peri-implant sulcus fluid (PISF) in implants with and without peri-implantitis. Methods Patients who simultaneously had dental implants with peri-implantitis and without peri-implantitis were included in the study. Forty-four samples with peri-implantitis and 34 samples without peri-implantitis from 16 patients were obtained. Intraoral evaluations such as pocket depth, modified sulcus bleeding index, and modified plaque index were noted. Enzyme-linked immunosorbent assay was used for the evaluation of PISF LL-37 and proteinase 3 levels. Results PISF volume was significantly increased in the implants with peri-implantitis than those without peri-implantitis (p< 0.05). No difference was present between PISF LL-37 and proteinase 3 total amounts between the implants with and without peri-implantitis (p> 0.05). Pocket depths and PISF LL-37 and proteinase 3 levels were not correlated in the groups (p> 0.05). Conclusions PISF volume might be increased in response to peri-implant bone destruction. However, peri-implant tissue destruction caused by peri-implantitis does not seem to affect PISF LL-37 and proteinase 3 levels.
dc.identifier.other2198-4034
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/8372
dc.language.isoEnglish
dc.publisherSPRINGER JAPAN KK
dc.subjectGINGIVAL CREVICULAR FLUID
dc.subjectANTIMICROBIAL PEPTIDES
dc.subjectCATHELICIDIN LL-37
dc.subjectBIOMARKER LEVELS
dc.subjectNATURAL TEETH
dc.subjectEXPRESSION
dc.subjectINTERLEUKIN-8
dc.subjectOSTEOCALCIN
dc.subjectPREVALENCE
dc.subjectELASTASE
dc.titleDoes peri-implant bone loss affect the LL-37 and proteinase 3 levels in peri-implant sulcus fluid?
dc.typeArticle

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