Acute responses of strength-related gene expressions to maximum strength and force sense acuity
| dc.contributor.author | Altun M. | |
| dc.contributor.author | Balcan E. | |
| dc.contributor.author | Batir S. | |
| dc.contributor.author | Gökmen M.H. | |
| dc.contributor.author | Özgüneş Ş. | |
| dc.contributor.author | Öztel Z. | |
| dc.date.accessioned | 2025-04-10T11:02:51Z | |
| dc.date.available | 2025-04-10T11:02:51Z | |
| dc.date.issued | 2024 | |
| dc.description.abstract | Background/aim: Although high muscle strength worsens the sense of force, it is unknown whether there is a relationship between this deterioration and the underlying molecular mechanisms. This study examined the relationship between decreased force sense (FS) acuity and strength-related gene expressions. Materials and methods: Maximal voluntary isometric contraction (MVIC) and FS (50% MVIC) tests were performed on the knee joints of twenty-two subjects. The expression analyses were evaluated by qRT-PCR in blood samples taken before, after MVIC, after 50% MVIC, and 15 min after the test. Results: MVIC and FS error values were significantly correlated with each other (r = .659, p = .001). The qRT-PCR analyses demonstrated that the expressed mRNAs of the interleukin 6 (IL-6), alpha-actinin 3 (ACTN3), angiotensin-converting enzyme (ACE), brain-derived neurotrophic factor (BDNF), and ciliary neurotrophic factor receptor (CNTFR) genes dramatically increased until 50% MVIC and subsequently decreased 15 min after the exercise (p <.05). The muscle-specific creatine kinase (CKMM), myosin light chain kinase (MLCK), and G-protein β3 subunit (GNB3) genes reached their peak expression levels 30 min after MVIC (p < .05). ACE and ACTN3 gene expression increased significantly in parallel with the increased FS error (p <.05). These gene expression fluctuations observed at 50% MVIC and after the rest could be related to changes in cellular metabolism leading to fatigue. Conclusion: The time points of gene expression levels during exercise need to be considered. The force acuity of those whose maximal force develops too much may deteriorate. © TÜBİTAK. | |
| dc.identifier.DOI-ID | 10.55730/1300-0144.5775 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/44313 | |
| dc.publisher | Turkiye Klinikleri | |
| dc.title | Acute responses of strength-related gene expressions to maximum strength and force sense acuity | |
| dc.type | Article |