Antenatal administration of granulocyte-macrophage colony-stimulating factor increases fetal lung maturation and endothelial nitric oxide synthase expression in the fetal rat lung
| dc.contributor.author | Baytur Y.B. | |
| dc.contributor.author | Ozbilgin K. | |
| dc.contributor.author | Yuksel H. | |
| dc.contributor.author | Kose C. | |
| dc.date.accessioned | 2025-04-10T11:16:36Z | |
| dc.date.available | 2025-04-10T11:16:36Z | |
| dc.date.issued | 2008 | |
| dc.description.abstract | Objectives: We investigated how maternal administration of granulocyte-macrophage colony-stimulating factor (GM-CSF) induced fetal lung maturation compared with dexamethasone and whether maternal administration of GM-CSF and dexamethasone influenced the fetal lung eNOS expression. Study design: Thirty pregnant rats were divided into three groups of 10 rats each to receive GM-CSF, dexamethasone or saline solution at 16 days of gestation. Lung maturation using bronchial area and immunohistochemical lung airway epithelium and the vascular endothelial eNOS expression, using H Scores, were evaluated at 18 and 20 days of gestation. The statistical analysis was done with the Kruskal-Wallis test for comparisons of more than two groups and the Mann-Whitney U-test as a post hoc test using SPSS for windows release 10.0. Values of p > 0, 0.05 were considered significant. Results: On the 20th day of gestation both GM-CSF and dexamethasone injections caused a significant increase in fetal lung bronchial area, as compared with the controls (24.9%, 36.8%, 13.4%, respectively, p = 0.001). eNOS immunoreactivity was observed in the endothelium of large pulmonary vessels and large and small airway epithelium on the 18th and 20th day of gestation. Maternal GM-CSF and dexamethasone increased lung eNOS expression in the airway epithelium when compared to controls. Conclusion: Maternal administration of GM-CSF induced fetal lung maturation and this effect may be mediated, at least partly, by an increase in the eNOS expression. © 2007 Elsevier Ireland Ltd. All rights reserved. | |
| dc.identifier.DOI-ID | 10.1016/j.ejogrb.2007.03.010 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/51936 | |
| dc.publisher | Elsevier Ireland Ltd | |
| dc.title | Antenatal administration of granulocyte-macrophage colony-stimulating factor increases fetal lung maturation and endothelial nitric oxide synthase expression in the fetal rat lung | |
| dc.type | Article |