Pretreatment serum albumin level is an independent prognostic factor in patients with stage IIIB non-small cell lung cancer: A study of the Turkish descriptive oncological researches group

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dc.contributor.authorTanriverdi O.
dc.contributor.authorAvci N.
dc.contributor.authorOktay E.
dc.contributor.authorKalemci S.
dc.contributor.authorPilanci K.N.
dc.contributor.authorCokmert S.
dc.contributor.authorMenekse S.
dc.contributor.authorKocar M.
dc.contributor.authorSen C.A.
dc.contributor.authorAkman T.
dc.contributor.authorOrdu C.
dc.contributor.authorGoksel G.
dc.contributor.authorMeydan N.
dc.contributor.authorBarutca S.
dc.date.accessioned2025-04-10T11:10:47Z
dc.date.available2025-04-10T11:10:47Z
dc.date.issued2015
dc.description.abstractBackground: Several prognostic factors have been studied in NSCLC, although it is unknown which is most useful. In this study, we aimed to investigate whether pre-treatment serum albumin level has prognostic value in patients with Stage IIIB NSCLC. Materials and Methods: This cross-sectional study included a total of 204 patients with Stage IIIB NSCLC who met the inclusion criteria. Pre-treatment serum albumin levels and demographic, clinical, and histological characteristics, as well as laboratory variables were recorded. A cut-off value was defined for serum albumin level and the patients were stratified into four groups on thios basis. Results: The majority of the patients was males and smokers, with a history of weight loss, and squamous histological type of lung cancer. The mean serum albumin level was 3.2±1.7 g/dL (range, 2.11-4.36 g/dL). A cut-off value 3.11 g/dL was set and among the patients with a lower level, 68% had adenocarcinoma and 82% were smokers. The patients with low serum albumin levels had a lower response rate to e first-line chemotherapy with a shorter progression-free survival and overall survival. Multivariate analysis showed that low serum albumin level was an independent poor prognostic factor for NSCLC. Conclusions: This study results suggest that low serum albumin level is an independent poor prognostic factor in patients with Stage IIIB NSCLC, associated with reduction in the response rate to first-line therapy and survival rates.
dc.identifier.DOI-ID10.7314/APJCP.2015.16.14.5971
dc.identifier.urihttp://hdl.handle.net/20.500.14701/49311
dc.publisherAsian Pacific Organization for Cancer Prevention
dc.titlePretreatment serum albumin level is an independent prognostic factor in patients with stage IIIB non-small cell lung cancer: A study of the Turkish descriptive oncological researches group
dc.typeArticle

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