Is Melatonin Protective in Contrast Material Related Renal Failure?

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dc.contributor.authorTuncyurek, O
dc.contributor.authorGunay, O
dc.contributor.authorTaneli, F
dc.contributor.authorAyhan, S
dc.contributor.authorNese, N
dc.contributor.authorPabuscu, Y
dc.date.accessioned2024-07-18T12:00:51Z
dc.date.available2024-07-18T12:00:51Z
dc.description.abstractAim: The aim of the study was to investigate the effect of melatonin on the renal injury resulting from radiocontrast media and myoglobinuria in male Wistar albino rats. Material and Method: 50% glycerol at equal amounts was intramuscularly administered to both hind legs of all animals under ether anesthesia at the dose of 10 mg/kg. Three hours later, the groups were administered the following: Group I (number: 7): Iopromide(Ultravist -300 (R)) at the dose of 2 ml/kg (intracardiac); Group II (number: 7): Iopromide(Ultravist -300 (R)) and intraperitoneally administered Melatonin at the dose of 10 mg/kg (Melatonin was dissolved in 7.5% absolute ethanol and further dilutions were made in saline.); and Group III (number: 7): 2 ml/kg of sterile physiologic saline (Control group). The levels of Uurea, Ccreatinine and Ccystatin C were studied on the blood samples collected. The renal samples were evaluated by 2two distinct pathologists who did not know the protocol. Results: There was no difference in the values of Creatinine and cystatin c between Groups 2 and 3 (p=0.9; 0.2). Discussion: In conclusion, we evaluated the possible prevention of contrast-induced oxidative stress in the kidney with using melatonin. However, additional clinical studies are needed to evaluate the role of preventive melatonin treatment in humans.
dc.identifier.issn1309-0720
dc.identifier.other1309-2014
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/8005
dc.language.isoEnglish
dc.publisherDERMAN MEDICAL PUBL
dc.subjectOXIDATIVE STRESS
dc.subjectINDUCED NEPHROTOXICITY
dc.subjectDISEASE
dc.subjectINJURY
dc.subjectDYSREGULATION
dc.subjectINFLAMMATION
dc.subjectUREMIA
dc.titleIs Melatonin Protective in Contrast Material Related Renal Failure?
dc.typeArticle

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