Effect of Biphosphonate Treatment on Femur Head Avascular Necrosis
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Date
2023
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Abstract
Avascular necrosis (AVN) is a progressive disorder that results in partial or complete death of bone tissue cells due to impaired blood circulation in the bone. The most common etiological factors in AVN formation are alcoholism, corticosteroid use, trauma, sickle cell anemia, systemic lupus erythematosus, and fat embolism. Among these, corticosteroid use is the most crucial risk factor for femoral head AVN development. Promising results regarding the efficiency of bisphosphonates-alendronate in treatment have been reported in a limited number of literature sources. In this article, a patient who developed bilateral AVN of the femoral head due to corticosteroid use after kidney transplantation and received alendronate treatment for 4 years due to osteoporosis is presented. It was thought that alendronate treatment started before the femoral head collapsed provided symptomatic relief in the hip joints.