Investigation of therapeutic efficiency of phenytoin (PHT) labeled with radioactive 131I in the cancer cell lines

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dc.contributor.authorUzaras C.
dc.contributor.authorAvcıbaşı U.
dc.contributor.authorDemiroğlu H.
dc.contributor.authorMedine E.İ.
dc.contributor.authorKılçar A.Y.
dc.contributor.authorMüftüler F.Z.B.
dc.contributor.authorÜnak P.
dc.date.accessioned2025-04-10T11:09:41Z
dc.date.available2025-04-10T11:09:41Z
dc.date.issued2016
dc.description.abstractThe aim of this study is to determine the incorporations of PHT radiolabeled with 131I (131I-PHT) on U-87 MG, Daoy and A549 cancerous cell lines. For this, cold and radio-labeling studies were carried out. The radio-labeling yield of 131I-PHT was obtained about 95 %. Subsequently, cell culture studies were carried out and radio-labeling yields of 131I, 131I-PHT on U-87 MG, Daoy and A549 cancerous cells were investigated. Cell culture studies demonstrated that the incorporation values of 131I-PHT on the three cell lines decreased with increasing radioactivity. Consequently, 131I-PHT may be a good radiopharmaceutical for targeting radionuclide therapy of Central Nervous System Tumors. © 2015, Akadémiai Kiadó, Budapest, Hungary.
dc.identifier.DOI-ID10.1007/s10967-015-4119-0
dc.identifier.urihttp://hdl.handle.net/20.500.14701/48914
dc.publisherSpringer Netherlands
dc.titleInvestigation of therapeutic efficiency of phenytoin (PHT) labeled with radioactive 131I in the cancer cell lines
dc.typeArticle

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