English
| dc.contributor.author | Berdeli, A | |
| dc.contributor.author | Cam, FS | |
| dc.date.accessioned | 2024-07-18T11:58:02Z | |
| dc.date.available | 2024-07-18T11:58:02Z | |
| dc.description.abstract | SPRINGER/PLENUM PUBLISHERS | |
| dc.identifier.issn | 1573-4927 | |
| dc.identifier.uri | http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/7217 | |
| dc.language.iso | Article | |
| dc.publisher | 0006-2928 | |
| dc.subject | Angiotensin converting enzyme (ACE) plays an essential role in the renin-angiotensin system. It converts angiotensin I to angiotensin II and inactivates bradykinin and tachykinins. Numerous studies have been published investigating associations of the ACE gene I/D polymorphism with various pathophysiological conditions. We examined the prevalence of the ACE I/D polymorphism in a sample of healthy volunteers from western Turkey, including 1063 healthy Turkish controls. Analysis of the ACE I/D gene polymorphisms by polymerase chain reaction found frequencies of 16.1% for the II genotype, 47.7% for the ID genotype, and 36.2% for the DD genotype. The allele frequency was 39.9% for the I alleles and 60.1% for the D allele. This study demonstrates that the allele and genotype frequency values for the Turkish population are similar to previously published frequencies for Caucasian populations. | |
| dc.title | English | |
| dc.type | CORONARY HEART-DISEASE | |
| dc.type | DELETION POLYMORPHISM | |
| dc.type | RISK-FACTOR | |
| dc.type | CARDIOVASCULAR-DISEASE | |
| dc.type | DIABETES-MELLITUS | |
| dc.type | I/D POLYMORPHISM | |
| dc.type | BLOOD-PRESSURE | |
| dc.type | D-ALLELE | |
| dc.type | ACE | |
| dc.type | HYPERTENSION |