Factors affecting treatment success in community-acquired pneumonia
No Thumbnail Available
Date
2016
Journal Title
Journal ISSN
Volume Title
Abstract
Background/aim: Treatment failure in hospitalized patients with community-acquired pneumonia is a major cause of mortality. The aim of this study was to evaluate the factors affecting treatment success in community-acquired pneumonia. Materials and methods: A total of 537 patients (mean age: 66.1 ± 15.8 years, 365 males) registered to the Turkish Thoracic Society Pneumonia Database were analyzed. Of these, clinical improvement or cure, defined as treatment success, was achieved in 477, whereas 60 patients had treatment failure and/or died. Results: Lower numbers of neutrophils (5989.9 ± 6237.3 vs. 8495.6 ± 7279.5/mm3), higher blood urea levels (66.1 ± 42.1 vs. 51.2 ± 38.2 mg/dL), higher Pneumonia Severity Index (PSI) scores (123.3 ± 42.6 vs. 96.3 ± 32.9), higher CURB-65 scores (2.7 ± 1.2 vs. 2.2 ± 0.9), lower PaO2/FiO2 ratios (216.3 ± 86.8 vs. 269.9 ± 65.6), and the presence of multilobar (33.3% vs. 16.4%) and bilateral (41.7% vs. 18.9%) radiologic infiltrates were related to treatment failure. The PSI score and PaO2/FiO2 ratio were independent parameters affecting treatment results in multivariate linear regression analysis (P < 0.001). Conclusion: The risk of treatment failure is high in patients with severe pneumonia and with respiratory failure. Effective treatment and close monitoring are required for these cases. © TÜBİTAK.
Description
Keywords
Aged , Aged, 80 and over , Community-Acquired Infections , Female , Humans , Male , Middle Aged , Multivariate Analysis , Pneumonia , Prognosis , Severity of Illness Index , Treatment Outcome , albumin , C reactive protein , procalcitonin , aged , antibiotic therapy , arterial oxygen tension , Article , bacterial pneumonia , breathing rate , community acquired pneumonia , female , hospitalization , human , leukocyte count , major clinical study , male , mortality rate , neutrophil count , pleura effusion , Pneumonia Severity Index , respiratory failure , retrospective study , treatment failure , urea nitrogen blood level , community acquired infection , middle aged , multivariate analysis , pneumonia , prognosis , severity of illness index , treatment outcome , very elderly