Factors affecting treatment success in community-acquired pneumonia

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dc.contributor.authorGündüz C.
dc.contributor.authorTaşbakan M.S.
dc.contributor.authorSayiner A.
dc.contributor.authorÇilli A.
dc.contributor.authorKilinç O.
dc.contributor.authorŞakar Coşkun A.
dc.date.accessioned2024-07-22T08:12:22Z
dc.date.available2024-07-22T08:12:22Z
dc.date.issued2016
dc.description.abstractBackground/aim: Treatment failure in hospitalized patients with community-acquired pneumonia is a major cause of mortality. The aim of this study was to evaluate the factors affecting treatment success in community-acquired pneumonia. Materials and methods: A total of 537 patients (mean age: 66.1 ± 15.8 years, 365 males) registered to the Turkish Thoracic Society Pneumonia Database were analyzed. Of these, clinical improvement or cure, defined as treatment success, was achieved in 477, whereas 60 patients had treatment failure and/or died. Results: Lower numbers of neutrophils (5989.9 ± 6237.3 vs. 8495.6 ± 7279.5/mm3), higher blood urea levels (66.1 ± 42.1 vs. 51.2 ± 38.2 mg/dL), higher Pneumonia Severity Index (PSI) scores (123.3 ± 42.6 vs. 96.3 ± 32.9), higher CURB-65 scores (2.7 ± 1.2 vs. 2.2 ± 0.9), lower PaO2/FiO2 ratios (216.3 ± 86.8 vs. 269.9 ± 65.6), and the presence of multilobar (33.3% vs. 16.4%) and bilateral (41.7% vs. 18.9%) radiologic infiltrates were related to treatment failure. The PSI score and PaO2/FiO2 ratio were independent parameters affecting treatment results in multivariate linear regression analysis (P < 0.001). Conclusion: The risk of treatment failure is high in patients with severe pneumonia and with respiratory failure. Effective treatment and close monitoring are required for these cases. © TÜBİTAK.
dc.identifier.DOI-ID10.3906/sag-1502-87
dc.identifier.issn13000144
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16033
dc.language.isoEnglish
dc.publisherTurkiye Klinikleri Journal of Medical Sciences
dc.rightsAll Open Access; Bronze Open Access
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectCommunity-Acquired Infections
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectMultivariate Analysis
dc.subjectPneumonia
dc.subjectPrognosis
dc.subjectSeverity of Illness Index
dc.subjectTreatment Outcome
dc.subjectalbumin
dc.subjectC reactive protein
dc.subjectprocalcitonin
dc.subjectaged
dc.subjectantibiotic therapy
dc.subjectarterial oxygen tension
dc.subjectArticle
dc.subjectbacterial pneumonia
dc.subjectbreathing rate
dc.subjectcommunity acquired pneumonia
dc.subjectfemale
dc.subjecthospitalization
dc.subjecthuman
dc.subjectleukocyte count
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmortality rate
dc.subjectneutrophil count
dc.subjectpleura effusion
dc.subjectPneumonia Severity Index
dc.subjectrespiratory failure
dc.subjectretrospective study
dc.subjecttreatment failure
dc.subjecturea nitrogen blood level
dc.subjectcommunity acquired infection
dc.subjectmiddle aged
dc.subjectmultivariate analysis
dc.subjectpneumonia
dc.subjectprognosis
dc.subjectseverity of illness index
dc.subjecttreatment outcome
dc.subjectvery elderly
dc.titleFactors affecting treatment success in community-acquired pneumonia
dc.typeArticle

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