Comparison of the radiopharmaceutical potentials of dithizone radiolabeled with 131I and with 99mTc

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dc.contributor.authorÜnak, T
dc.contributor.authorYildirim, Y
dc.contributor.authorAvcibasi, U
dc.contributor.authorBiber, Z
dc.contributor.authorDuman, Y
dc.contributor.authorÜnak, P
dc.date.accessioned2024-07-18T12:01:17Z
dc.date.available2024-07-18T12:01:17Z
dc.description.abstractIn this study, dithizone (diphenylthiocarbazone) has been separately radiolabeled with I-131 and with Tc-99m for preliminarily testing their radiopharmaceutical potentials on male albino rabbits. I-131-dithizone and Tc-99m-dithizone were intravenously injected to rabbits via their ear veins after anesthetizing with a mixture of Alfazyne and Alfamine (Serva) to determine their dynamic and static statuses in the metabolism. Also, Tc-99m as pertechnetate and I-131 as iodate were administered to rabbits as controls. Dynamic and static scintigrams were obtained using a gamma camera (Diacan Instruments). Dynamic scintigrams were obtained over the first half hour with frames of 1 minute following the administrations of the labeled compounds. Static images were obtained from posterior projection at different time intervals up to about 3 hours following the administration of the radiolabeled compounds. Tc-99m-dithizone was significantly uptaken by the pancreas in contrast to free Tc-99m. In the case of I-131-dithizone, the distribution of I-131 activity in the metabolism was clearly different than the case of free (131)stopI and the uptake of I-131-dithizone at the pancreas zone was also significant. These preliminary tests have clearly indicated that especially Tc-99m-dithizone has a significant potential to be used as a pancreatic radiopharmaceutical.
dc.identifier.issn0236-5731
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/8328
dc.language.isoEnglish
dc.publisherSPRINGER
dc.subjectPROSTATE-CANCER
dc.subjectZINC
dc.subjectINSULIN
dc.subjectRADIOIODINATION
dc.subjectGROWTH
dc.subjectCELLS
dc.titleComparison of the radiopharmaceutical potentials of dithizone radiolabeled with 131I and with 99mTc
dc.typeArticle

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