Glucagon-like peptide-1: Review; [Glukagon like peptid-1]

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dc.contributor.authorGüçlü F.
dc.contributor.authorÖzmen B.
dc.contributor.authorHekimsoy Z.
dc.contributor.authorÖzkaya Kafesçiler S.
dc.date.accessioned2024-07-22T08:22:57Z
dc.date.available2024-07-22T08:22:57Z
dc.date.issued2007
dc.description.abstractGlucagon-like peptide-1 (GLP-1) is a 30 amino-acid hormone produced by the pancreatic islet alpha cells, intestinal-L cells and central nervous sytem cells. The main target of action of GLP-1 is the islet, where the hormone stimulates insulin secretion, promotes beta cell proliferation and neogenesis, and inhibits glucagon secretion. However, GLP-1 receptors are also expressed outside the islets, increasing the likelihood that GLP-1 also plays a role in other organs. These functions are mainly the inhibition of gastric emptying, gastric acid secretion and exocrine pancreatic secretion, indicating that the hormone acts as an enterogastrone hormone released from the distal portion of the small intestine that inhibits proximal gastrointestinal events. Another important action of GLP-1 is to induce satiety. Other effects of the hormone include cardioprotection, neuroprotection, induction of antidiabetic actions unrelated to islet function. Thus, GLP-1 clearly has several manifestations of activity. The physiological relevance of these actions and their contribution to the overall antidiabetic action of GLP-1 when used in treatment of type 2 diabetes remains to be established. Copyright © 2007 by Türkiye Klinikleri.
dc.identifier.issn13000292
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19312
dc.language.isoTurkish
dc.publisherTurkiye Klinikleri
dc.subject6 [[2 [[2 (2 cyano 1 pyrrolidinyl) 2 oxoethyl]amino]ethyl]amino]nicotinonitrile
dc.subjectcjc 1131
dc.subjectdipeptidyl peptidase IV inhibitor
dc.subjectexendin 4
dc.subjectglucagon
dc.subjectglucagon like peptide 1
dc.subjecthemoglobin A1c
dc.subjectinsulin
dc.subjectliraglutide
dc.subjectmetformin
dc.subjectplacebo
dc.subjectsulfonylurea
dc.subjectvildagliptin
dc.subjectAlzheimer disease
dc.subjectcardiovascular system
dc.subjectdiabetes control
dc.subjectdiabetes mellitus
dc.subjectgastrointestinal tract
dc.subjectglucagon release
dc.subjectheart protection
dc.subjecthormone action
dc.subjecthormone release
dc.subjecthuman
dc.subjectinsulin release
dc.subjectneuroprotection
dc.subjectnon insulin dependent diabetes mellitus
dc.subjectoxidative stress
dc.subjectpancreas islet alpha cell
dc.subjectpancreas islet beta cell
dc.subjectreview
dc.subjectstomach acid secretion
dc.subjectstomach emptying
dc.titleGlucagon-like peptide-1: Review; [Glukagon like peptid-1]
dc.typeReview

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