Phenolic profile, antioxidant and enzyme inhibitory potential of Onosma tauricum var. tauricum

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dc.contributor.authorKirkan, B
dc.contributor.authorSarikurkcu, C
dc.contributor.authorOzer, MS
dc.contributor.authorCengiz, M
dc.contributor.authorAtilgan, N
dc.contributor.authorCeylan, O
dc.contributor.authorTepe, B
dc.date.accessioned2024-07-18T12:01:03Z
dc.date.available2024-07-18T12:01:03Z
dc.description.abstractThis study focused on phytochemical characterization and biological evaluation, both antioxidant and enzymatic inhibition, of ethyl acetate (OTT-EtOAc), methanol (OTT-MeOH), and water (OTT-W) extracts from Onosma tauricum var. tauricum aerial parts. The OTT-W extract was found to be the richest one in terms of its phenolic and flavonoid contents. Amounts of the phenolic and flavonoid compounds were determined as 40.88 mu mol GAEs/g and 7.40 mu mol REs/g dry plant (dp), respectively. The OTT-MeOH and OTT-W extracts were also found to contain significant amounts of chlorogenic acid, rosmarinic acid, p-hydroxybenzoic acid, caffeic acid, rutin, p-coumaric acid, trans-cinnamic acid, luteolin, and apigenin. The OTT-W extract showed remarkable antioxidant activity in phosphomolybdenum, ferrous ion chelating, reducing power, and radical scavenging assays. The OTT-MeOH extract exhibited inhibitory activity on acetylcholinesterase (AChE) (54.62 mu mol GALAEs/g dp), while the extracts remained almost inactive on butyrylcholinesterase (BChE). The OTT-W extract also exhibited inhibitory activity on tyrosinase (90.66 mu mol KAEs/g dp) and alpha-glucosidase (2258.87 mu mol ACEs/g dp). The results suggest that especially the OTT-MeOH and OTT-W extracts can be used as a source of alternative natural products in the treatment of diseases caused by the enzymes evaluated here.
dc.identifier.issn0926-6690
dc.identifier.other1872-633X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/8161
dc.language.isoEnglish
dc.publisherELSEVIER
dc.subjectALPHA-GLUCOSIDASE
dc.subjectL. BORAGINACEAE
dc.subjectTYROSINASE
dc.subjectEXTRACTS
dc.subjectPLANTS
dc.subjectALKANNIN/SHIKONIN
dc.subjectANTIBACTERIAL
dc.subjectARGENTATUM
dc.subjectDOPAMINE
dc.subjectAMYLASE
dc.titlePhenolic profile, antioxidant and enzyme inhibitory potential of Onosma tauricum var. tauricum
dc.typeArticle

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