The impact of smoking on response to tumor necrosis factor-α inhibitor treatment in patients with ankylosing spondylitis

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dc.contributor.authorTugsal, HY
dc.contributor.authorKenar, G
dc.contributor.authorCan, G
dc.contributor.authorÇapar, S
dc.contributor.authorZengin, B
dc.contributor.authorAkar, S
dc.contributor.authorDalkiliç, E
dc.contributor.authorSenel, S
dc.contributor.authorKoca, SS
dc.contributor.authorGoker, B
dc.contributor.authorYazici, A
dc.contributor.authorInanç, N
dc.contributor.authorEllidokuz, H
dc.contributor.authorAkkoç, N
dc.contributor.authorÖnen, F
dc.date.accessioned2024-07-18T12:07:55Z
dc.date.available2024-07-18T12:07:55Z
dc.description.abstractBackground/aim: To investigate the impact of smoking on disease activity, treatment retention, and response in patients with ankylosing spondylitis (AS) treated with their first tumor necrosis factor-alpha inhibitor (TNFi). Materials and methods: AS patients who started their first TNFi treatment for the active axial disease (BASDAI >= 4) from TURKBIO Registry were included. Treatment response of smoker (current and ex-smokers) and nonsmoker (never smoker) patients were primarily evaluated as achievement of BASDAI50 or improvement in BASDAI at least 20 mm at 3 months and 6 months compared to baseline. Results: There were 322 patients with AS (60% male, 59% smoker, mean age: 38.3 years). The median follow-up time was 2.8 years (Q1-Q3: 1.3-3.8), and disease duration was 3.5 years (Q1-Q3: 0.7-8.2). Smokers had male predominance (p < 0.001), lower ESR (p = 0.03), higher BASDAI (p = 0.02), BASFI (p = 0.05), HAQ-AS (p = 0.007), and ASDAS-CRP (p = 0.04) compared with nonsmokers at baseline. In the multivariate analysis, male gender [OR 2.7 (95%CI 1.4-5), p = 0.002], and concomitant conventional synthetic disease-modifying antirheumatic drug use [OR 2.4 (95%CI 1.1-5.2), p = 0.03] were associated with better treatment response. There was an association of male gender [HR 2.4 (95%CI 1.6-3.7), p < 0.001], older age (>= 30years) [HR 1.8 (95%CI 1.1-2.8), p = 0.01], and response to treatment [HR 1.8 (95%CI 1.2-2.9), p = 0.008] with better treatment retention. No impact of smoking status was found on treatment retention and response in univariate and multivariate analyses. Conclusion: This study suggested that smoking was associated with poorer patient-reported outcomes in biologic naive AS patients initiating their first TNFi treatment, but it had no impact on the TNFi treatment response and retention rate.
dc.identifier.issn1300-0144
dc.identifier.other1303-6165
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/10695
dc.language.isoEnglish
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.subjectQUALITY-OF-LIFE
dc.subjectACTIVITY SCORE ASDAS
dc.subjectANTI-TNF THERAPY
dc.subjectDISEASE-ACTIVITY
dc.subjectAXIAL SPONDYLOARTHRITIS
dc.subjectCIGARETTE-SMOKING
dc.subjectFUNCTIONAL ABILITY
dc.subjectSTRUCTURAL DAMAGE
dc.subjectPROGRESSION
dc.subjectSMOKERS
dc.titleThe impact of smoking on response to tumor necrosis factor-α inhibitor treatment in patients with ankylosing spondylitis
dc.typeArticle

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