Effects of octreotide and morphine on the clearance rate of indium-111-pentetreotide from the epidural space

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dc.contributor.authorAydin, Z
dc.contributor.authorSayit, E
dc.contributor.authorErkin, Y
dc.contributor.authorÇapa, G
dc.contributor.authorErtay, Y
dc.contributor.authorSagiroglu, E
dc.contributor.authorDurak, H
dc.date.accessioned2024-07-18T12:00:09Z
dc.date.available2024-07-18T12:00:09Z
dc.description.abstractIn this study we aimed to evaluate the possible mechanisms by which somatostatin acts when given epidurally. Twenty male New Zealand rabbits were randomly separated into four groups and various drugs were administered via a caudal epidural catheter. Group 1 received a bolus of 3.7 MBq indium-111 (In-111)-pentetreotide, group 2 received 200 mu g octreotide and after 15 min a bolus of 3.7 MBq In-111-pentetreotide, group 3 received 0.1 mg morphine and after 15 min a bolus of 3.7 MBq In-111-pentetreotide, and group 4 received a bolus of 3.7 MBq technetium-99m (Tc-99(m))-diethylene triamine pentaacetic acid (DTPA). Dynamic images of 60 min' duration were obtained from the posterior projection. T-1/2 fast and T-1/2 total clearance half-times were calculated. When unlabelled octreotide was given to block somatostatin receptors, clearance of In-111-pentetreotide was found to be faster. Epidural morphine administration did not change the clearance rate of In-111-pentetreotide. All these findings are in favour of octreotide binding to its probable own specific receptors present in the epidural space. ((C) 2000 Lippincott William & Wilkins).
dc.identifier.issn0143-3636
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/7510
dc.language.isoEnglish
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.subjectINTRATHECAL SOMATOSTATIN
dc.subjectSPINAL-CORD
dc.subjectABDOMINAL-SURGERY
dc.subjectMOTOR FUNCTION
dc.subjectNEURONS
dc.subjectINVIVO
dc.subjectPAIN
dc.subjectHISTOPATHOLOGY
dc.subjectNEUROTOXICITY
dc.subjectLOCALIZATION
dc.titleEffects of octreotide and morphine on the clearance rate of indium-111-pentetreotide from the epidural space
dc.typeArticle; Proceedings Paper

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