Preoperative Levels of Matrix Metalloproteinase-7 and-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 Relation to Pathologic Parameters in Bladder Carcinoma Patients

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dc.contributor.authorGunes, M
dc.contributor.authorKemik, AS
dc.contributor.authorPirincci, N
dc.contributor.authorGecit, I
dc.contributor.authorTaken, K
dc.contributor.authorYuksel, MB
dc.contributor.authorKaba, M
dc.contributor.authorEryilmaz, R
dc.date.accessioned2024-07-18T12:05:57Z
dc.date.available2024-07-18T12:05:57Z
dc.description.abstractOur aim was to test the hypothesis that preoperative serum levels of matrix metalloproteinase-7 (MMP-7) and -9 (MMP-9) and tissue inhibitor of matrix metalloproteinase (TIMP-1) levels correlate with pathological features. Serum levels of MMP-7, and MMP-9 and TIMP-1 were determined in 90 bladder cancer patients and 40 healthy controls using an enzyme linked immunosorbent assay. Preoperative serum MMP-7 and MMP-9 levels were significantly higher in cancer patients than control groups (p<0.001). In contast, serum TIMP-1 levels were lower (p<0.001). Alteration in MMP-7, and MMP-9, and TIMP-1 production may contribute to tumor angiogenesis and be associated with clinic-pathological features.
dc.identifier.issn1513-7368
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/10087
dc.language.isoEnglish
dc.publisherASIAN PACIFIC ORGANIZATION CANCER PREVENTION
dc.subjectSERUM-LEVELS
dc.subjectCANCER
dc.subjectMATRIX-METALLOPROTEINASE-9
dc.subjectEXPRESSION
dc.subjectSURVIVAL
dc.subjectMMP-9
dc.subjectMETASTASIS
dc.subjectPREDICTS
dc.subjectTIMP-1
dc.subjectDIAGNOSIS
dc.titlePreoperative Levels of Matrix Metalloproteinase-7 and-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 Relation to Pathologic Parameters in Bladder Carcinoma Patients
dc.typeArticle

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