Plasma Levels of Antioxidant Vitamins in Patients with Acromegaly: A Case-Control Study

Simple item page
dc.contributor.authorKutbay, NO
dc.contributor.authorYurekli, BS
dc.contributor.authorSimsir, IY
dc.contributor.authorSuner, A
dc.contributor.authorSeckiner, S
dc.contributor.authorKucukerdonmez, O
dc.contributor.authorSaygili, F
dc.date.accessioned2024-07-18T12:00:36Z
dc.date.available2024-07-18T12:00:36Z
dc.description.abstractOBJECTIVE: The aim of this study was to compare antioxidant vitamin C and vitamin E levels in the non-acromegaly control group and in patients with acromegaly with and without remission. MATERIAL AND METHODS: In this study, 100 cases, acromegaly patients of 57% (n=57, 29F, 28M, mean ages of 49.5 +/- 12.1) and control subjects of 43% (n=43, 29F, 14M, mean ages of 49.6 +/- 9.2). Acromegaly patients were classified into two groups; active acromegaly (AA; n=33) and controlled acromegaly (CA; n=24). RESULTS: Vitamin C levels were significantly lower in the acromegaly group [7.6 (4.7) mg/L, as median (IQR)] when compared to the control group [12.2 (5.5) mg/L, as median (IQR)] (p <0.001). Vitamin E levels didn't show a significant difference between the acromegaly and the control groups (14.2 +/- 3.6 vs. 14.8 +/- 3.7, as mean +/- SD, respectively, p = 0.439). Correlation analysis showed that vitamin C levels were not significantly associated with clinical, anthropometric and laboratory parameters in the acromegaly group. Vitamin E levels were significantly associated with the total cholesterol, triglyceride, LDL-C, HDL-C, APO A1, APO B both in the acromegaly and the control groups. CONCLUSION: This study is the first one to investigate the relationship between the levels of vitamin C & E and anthropometric & metabolic parameters in acromegaly patients and control group. In our study, vitamin C level was significantly lower in the acromegaly group compared to the level in the control group. There was no significant difference in vitamin E levels between the acromegaly and control group.
dc.identifier.issn0172-780X
dc.identifier.other2354-4716
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/7827
dc.language.isoEnglish
dc.publisherMAGHIRA & MAAS PUBLICATIONS
dc.subjectCORONARY-HEART-DISEASE
dc.subjectOXIDATIVE STRESS
dc.subjectENDOTHELIAL DYSFUNCTION
dc.subjectLIPID-PEROXIDATION
dc.subjectCLINICAL-PRACTICE
dc.subjectASCORBIC-ACID
dc.subjectPHYSIOLOGY
dc.subjectPROFILE
dc.subjectUPDATE
dc.subjectIMPACT
dc.titlePlasma Levels of Antioxidant Vitamins in Patients with Acromegaly: A Case-Control Study
dc.typeArticle

Files

Collections

Web of Science Koleksiyonu