Influence of radiation exposure during radiotherapy: Evidence for the increase of versican and heparin-binding EGF-like growth factor concentrations

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dc.contributor.authorOzbilgin M.K.
dc.contributor.authorAktas C.
dc.contributor.authorUluer E.T.
dc.contributor.authorBuyukuysal M.C.
dc.contributor.authorGareveran M.S.
dc.contributor.authorKurtman C.
dc.date.accessioned2025-04-10T11:09:20Z
dc.date.available2025-04-10T11:09:20Z
dc.date.issued2016
dc.description.abstractOBJECTIVE: To investigate the reaction of versican and heparin-binding EGF-like growth factor (HB-EGF) molecule concentrations to acute radiation exposure in normal bladder and rectal tissue samples in order to gain more insight into the effects of cancer radiotherapy. STUDY DESIGN: Four groups with 6 male adult Swiss Albino mice per group were investigated. The mice bladder and rectum tissue samples were subjected to a 10-Gy single-dose radiation exposure in the pelvic region with a Co-60 teletherapy device and investigated 1, 2, and 7 days after radiation exposure, with 1 reference group which was not exposed to radiation. RESULTS: In the immunohistochemical examination of the tissue samples with anti-versican and anti-HB-EGF primary antibodies was observed a statistically significant increase 7 days after radiation exposure. CONCLUSION: The observed increase of versican and HB-EGF concentrations in the normal tissue matrix after radiation exposure may play a role in the side effects of radiotherapy. © Science Printers and Publishers, Inc.
dc.identifier.urihttp://hdl.handle.net/20.500.14701/48666
dc.publisherScience Printers and Publishers Inc.
dc.titleInfluence of radiation exposure during radiotherapy: Evidence for the increase of versican and heparin-binding EGF-like growth factor concentrations
dc.typeArticle

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