Effects of rofecoxib, a selective cyclooxygenase-2 inhibitor, on endothelial dysfunction, lipid peroxidation, and hepatocyte morphology in rats with sepsis-induced liver damage

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dc.contributor.authorKara, E
dc.contributor.authorVar, A
dc.contributor.authorVatansever, S
dc.contributor.authorCilaker, S
dc.contributor.authorKaya, Y
dc.contributor.authorCoskun, T
dc.date.accessioned2024-07-18T11:48:45Z
dc.date.available2024-07-18T11:48:45Z
dc.description.abstractBackground: Sepsis remains a difficult problem for clinicians, with its systemic effects and high morbidity and mortality rates. The roles of oxidative stress, endothelial dysfunction, and lipid peroxidation in sepsis-induced organ damage are being investigated. Objective: The aim of this study was to investigate the effects of selective cyclooxygenase (COX)-2 inhibition on tissue lipid peroxidation, endothelial dysfunction, and hepatic cell morphology in a rat model of sepsis. Methods: Thirty rats with sepsis induced by cecal ligation and puncture were divided equally into 3 groups: treatment group (rofecoxib 1 mg/kg PO), control group (saline 1 ml, PO), and sham group (sham surgery only). All the rats were sacrificed I day after sepsis induction. The livers were removed using a median laparotomy for histopathologic and biochemical analysis. Results: Histomorphologic hepatic damage and lipid peroxidation were significantly reduced in the rofecoxib treatment group compared with the control group (P < 0.05 and P = 0.001, respectively). Endothelial nitric oxide synthase and inducible nitric oxide synthase staining of liver samples was statistically significantly reduced in the treatment group compared with the control group (both, P < 0.001). The hepatic nitric oxide level and malonyldialdehyde activity decreased significantly (,P < 0.001 and P = 0.001, respectively) in the rofecoxib group compared with the control group. Hepatic myeloperoxidase activity was similar between the treatment and control groups. Conclusion: Further investigation of selective COX-2 inhibition as an alternate therapeutic choice for sepsis-induced hepatic damage should be considered.
dc.identifier.issn0011-393X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/3473
dc.language.isoEnglish
dc.publisherEXCERPTA MEDICA INC
dc.subjectNITRIC-OXIDE SYNTHASE
dc.subjectSEPTIC SHOCK
dc.subjectFREE-RADICALS
dc.subjectENDOTOXIC-SHOCK
dc.subjectTISSUE-INJURY
dc.subjectSURVIVAL
dc.subjectMICE
dc.subjectALPHA
dc.subjectPERITONITIS
dc.subjectMODULATION
dc.titleEffects of rofecoxib, a selective cyclooxygenase-2 inhibitor, on endothelial dysfunction, lipid peroxidation, and hepatocyte morphology in rats with sepsis-induced liver damage
dc.typeArticle

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