Effectiveness and Safety of Initiation and Titration of Insulin Glargine 300 U/mL in Insulin-Naive Patients with Type 2 Diabetes Mellitus Uncontrolled on Oral Antidiabetic Drug Treatment in Turkey: The EASE Study

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dc.contributor.authorÇetinarslan, B
dc.contributor.authorÇetinkalp, S
dc.contributor.authorKaya, A
dc.contributor.authorErsoy, C
dc.contributor.authorKebapçi, N
dc.contributor.authorÇömlekçi, A
dc.contributor.authorTütüncü, NB
dc.contributor.authorDeyneli, O
dc.contributor.authorOguz, A
dc.contributor.authorIlkova, H
dc.contributor.authorYilmaz, T
dc.contributor.authorHekimsoy, Z
dc.contributor.authorÜnübol, M
dc.contributor.authorBalci, MK
dc.contributor.authorAtmaca, A
dc.contributor.authorDagdelen, S
dc.contributor.authorYetkin, I
dc.contributor.authorGüler, S
dc.contributor.authorÖtünç, G
dc.contributor.authorÖzhan, L
dc.date.accessioned2024-07-18T12:08:20Z
dc.date.available2024-07-18T12:08:20Z
dc.description.abstractObjective: The aim of the study was to evaluate the effectiveness and safety of insulin glargine 300 U/ mL (Gla-300) in insulin-naive patients with type 2 diabetes mellitus (T2DM) inadequately controlled on oral antidiabetic drug (OADs) treatment in Turkey. Methods: One hundred eight patients from 20 centers enrolled in the study. Starting from baseline, Gla-300 was self-administered subcutaneously and once daily in the evening. The primary outcome was the mean change in glycated hemoglobin A1c (HbA1c) from baseline to week 24. Results: The mean (+/- SD) Hb1Ac level of 9.4% (+/- 0.8) at baseline decreased to 7.5% (+/- 0.9) at week 12 (P < .1) and to 7.3% (+/- 0.9) at week 24 (P < .1). Although none of the patients were within the target Hb1Ac level of <= 7% at baseline, the percentage of patients who achieved the target Hb1Ac level was 30.4% at week 12 and increased to 42.9% at week 24. Gla-300 treatment achieved the Hb1Ac target in 21 (19.4%) patients without experiencing a hypoglycemic event and in 27 (25.0%) patients who experienced at least one hypoglycemic event. For each self-monitoring blood glucose time point, significant improvements were observed as compared to baseline (P < .001). Statistically significant improvement (P < .001) was seen in the treatment satisfaction questionnaire - status version scores between baseline and week 24. Conclusion: This study indicated that Gla-300 is effective to provide a successful glycemic control with low risk of hypoglycemia added to OADs in insulin-naive patients with T2DM, and it has the potential to improve the quality of life of patients.
dc.identifier.other2822-6135
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/10897
dc.language.isoEnglish
dc.publisherAVES
dc.subjectCLINICAL INERTIA
dc.subjectGLYCEMIC CONTROL
dc.subjectTHERAPY
dc.subjectMANAGEMENT
dc.subjectPEOPLE
dc.subjectHYPOGLYCEMIA
dc.titleEffectiveness and Safety of Initiation and Titration of Insulin Glargine 300 U/mL in Insulin-Naive Patients with Type 2 Diabetes Mellitus Uncontrolled on Oral Antidiabetic Drug Treatment in Turkey: The EASE Study
dc.typeArticle

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