The effect of inhaled corticosteroids in the outcomes of community-acquired pneumonia: ICCAP study (TURKCAP Database)
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Date
2020
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Abstract
Objective: We aimed to investigate the effect of inhaled corticosteroids (ICS) in the outcomes of community-acquired pneumonia (CAP), as well as to determine if ICS usage is exist among the risk factors for mortality in those patients. Materials and Methods: In this retrospective cross-sectional multicentre study, 1069 hospitalised CAP patients were investigated using CAP Database of Turkish Thoracic Society (TURKCAP Database). The patients were divided into two groups, depending on their ICS use. The data were analysed by appropriate statistical methods. Results: 172 (75.8%) of the 227 patients who were on ICS had COPD and 37 (16.3%) had asthma. There were fewer patients with fever among ICS-users compared to non-ICS users (P = 0.013), and less muscle pain (P = 0.015) and fewer GIS symptoms (P = 0.022). No statistically significant difference was found between ICS use/ type of ICS and the duration of hospitalisation (P = 0.286). The multivariate regression analysis showed that patients using ICS had lower body temperature and, less crackles/bronchial sound. In the multivariate logistic regression model lung cancer (OR: 6.75), glucose (OR: 1.01) and CURB-65 (OR: 1.72) were significantly associated with mortality in the CAP patients. ICS usage were not found to be associated with mortality. Conclusion: The use of ICS by the patients with CAP admitted to the hospital is not independently related with any radiological pattern, hospitalisation duration and mortality. ICS usage may diminish fever response and may suppress the findings of crackles and/or bronchial sounds. This needs further confirmation. © 2020 John Wiley & Sons Ltd
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Administration, Inhalation , Adult , Aged , Community-Acquired Infections , Cross-Sectional Studies , Female , Glucocorticoids , Hospital Mortality , Hospitalization , Humans , Logistic Models , Male , Middle Aged , Pneumonia , Retrospective Studies , Risk Factors , Survival Rate , Treatment Outcome , Turkey , corticosteroid , glucose , glucocorticoid , adult , Article , asthma , body temperature , chronic obstructive lung disease , clinical feature , community acquired pneumonia , crackle , cross-sectional study , disease association , disease duration , drug effect , female , fever , glucose level , hospital mortality , hospitalization , human , lung cancer , major clinical study , male , middle aged , mortality rate , multicenter study (topic) , multivariate logistic regression analysis , myalgia , Pneumonia Severity Index , priority journal , retrospective study , risk factor , symptom , thorax radiography , treatment outcome , treatment response , aged , clinical trial , community acquired infection , inhalational drug administration , mortality , multicenter study , pneumonia , statistical model , survival rate , treatment outcome , turkey (bird)