The effect of inhaled corticosteroids in the outcomes of community-acquired pneumonia: ICCAP study (TURKCAP Database)

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dc.contributor.authorBaha A.
dc.contributor.authorKokturk N.
dc.contributor.authorBahcecioglu S.N.
dc.contributor.authorYapar D.
dc.contributor.authorAksakal N.
dc.contributor.authorGündüz C.
dc.contributor.authorTasbakan S.
dc.contributor.authorSayiner A.
dc.contributor.authorCoskun A.S.
dc.contributor.authorDurmaz F.
dc.contributor.authorCilli A.
dc.contributor.authorCelenk B.
dc.contributor.authorKılınc O.
dc.contributor.authorSalman S.
dc.contributor.authorHazar A.
dc.contributor.authorTokgoz F.
dc.date.accessioned2024-07-22T08:07:34Z
dc.date.available2024-07-22T08:07:34Z
dc.date.issued2020
dc.description.abstractObjective: We aimed to investigate the effect of inhaled corticosteroids (ICS) in the outcomes of community-acquired pneumonia (CAP), as well as to determine if ICS usage is exist among the risk factors for mortality in those patients. Materials and Methods: In this retrospective cross-sectional multicentre study, 1069 hospitalised CAP patients were investigated using CAP Database of Turkish Thoracic Society (TURKCAP Database). The patients were divided into two groups, depending on their ICS use. The data were analysed by appropriate statistical methods. Results: 172 (75.8%) of the 227 patients who were on ICS had COPD and 37 (16.3%) had asthma. There were fewer patients with fever among ICS-users compared to non-ICS users (P = 0.013), and less muscle pain (P = 0.015) and fewer GIS symptoms (P = 0.022). No statistically significant difference was found between ICS use/ type of ICS and the duration of hospitalisation (P = 0.286). The multivariate regression analysis showed that patients using ICS had lower body temperature and, less crackles/bronchial sound. In the multivariate logistic regression model lung cancer (OR: 6.75), glucose (OR: 1.01) and CURB-65 (OR: 1.72) were significantly associated with mortality in the CAP patients. ICS usage were not found to be associated with mortality. Conclusion: The use of ICS by the patients with CAP admitted to the hospital is not independently related with any radiological pattern, hospitalisation duration and mortality. ICS usage may diminish fever response and may suppress the findings of crackles and/or bronchial sounds. This needs further confirmation. © 2020 John Wiley & Sons Ltd
dc.identifier.DOI-ID10.1111/crj.13145
dc.identifier.issn17526981
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13999
dc.language.isoEnglish
dc.publisherBlackwell Publishing Ltd
dc.subjectAdministration, Inhalation
dc.subjectAdult
dc.subjectAged
dc.subjectCommunity-Acquired Infections
dc.subjectCross-Sectional Studies
dc.subjectFemale
dc.subjectGlucocorticoids
dc.subjectHospital Mortality
dc.subjectHospitalization
dc.subjectHumans
dc.subjectLogistic Models
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPneumonia
dc.subjectRetrospective Studies
dc.subjectRisk Factors
dc.subjectSurvival Rate
dc.subjectTreatment Outcome
dc.subjectTurkey
dc.subjectcorticosteroid
dc.subjectglucose
dc.subjectglucocorticoid
dc.subjectadult
dc.subjectArticle
dc.subjectasthma
dc.subjectbody temperature
dc.subjectchronic obstructive lung disease
dc.subjectclinical feature
dc.subjectcommunity acquired pneumonia
dc.subjectcrackle
dc.subjectcross-sectional study
dc.subjectdisease association
dc.subjectdisease duration
dc.subjectdrug effect
dc.subjectfemale
dc.subjectfever
dc.subjectglucose level
dc.subjecthospital mortality
dc.subjecthospitalization
dc.subjecthuman
dc.subjectlung cancer
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmiddle aged
dc.subjectmortality rate
dc.subjectmulticenter study (topic)
dc.subjectmultivariate logistic regression analysis
dc.subjectmyalgia
dc.subjectPneumonia Severity Index
dc.subjectpriority journal
dc.subjectretrospective study
dc.subjectrisk factor
dc.subjectsymptom
dc.subjectthorax radiography
dc.subjecttreatment outcome
dc.subjecttreatment response
dc.subjectaged
dc.subjectclinical trial
dc.subjectcommunity acquired infection
dc.subjectinhalational drug administration
dc.subjectmortality
dc.subjectmulticenter study
dc.subjectpneumonia
dc.subjectstatistical model
dc.subjectsurvival rate
dc.subjecttreatment outcome
dc.subjectturkey (bird)
dc.titleThe effect of inhaled corticosteroids in the outcomes of community-acquired pneumonia: ICCAP study (TURKCAP Database)
dc.typeArticle

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