Neuropsychological testing of cognitive impairment in euthymic bipolar disorder: an individual patient data meta-analysis

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dc.contributor.authorBourne, C
dc.contributor.authorAydemir, Ö
dc.contributor.authorBalanzá-Martínez, V
dc.contributor.authorBora, E
dc.contributor.authorBrissos, S
dc.contributor.authorCavanagh, JTO
dc.contributor.authorClark, L
dc.contributor.authorCubukcuoglu, Z
dc.contributor.authorDias, VV
dc.contributor.authorDittmann, S
dc.contributor.authorFerrier, IN
dc.contributor.authorFleck, DE
dc.contributor.authorFrangou, S
dc.contributor.authorGallagher, P
dc.contributor.authorJones, L
dc.contributor.authorKieseppä, T
dc.contributor.authorMartínez-Aran, A
dc.contributor.authorMelle, I
dc.contributor.authorMoore, PB
dc.contributor.authorMur, M
dc.contributor.authorPfennig, A
dc.contributor.authorRaust, A
dc.contributor.authorSenturk, V
dc.contributor.authorSimonsen, C
dc.contributor.authorSmith, DJ
dc.contributor.authorBio, DS
dc.contributor.authorSoeiro-de-Souza, MG
dc.contributor.authorStoddart, SDR
dc.contributor.authorSundet, K
dc.contributor.authorSzöke, A
dc.contributor.authorThompson, JM
dc.contributor.authorTorrent, C
dc.contributor.authorZalla, T
dc.contributor.authorCraddock, N
dc.contributor.authorAndreassen, OA
dc.contributor.authorLeboyer, M
dc.contributor.authorVieta, E
dc.contributor.authorBauer, M
dc.contributor.authorWorhunsky, PD
dc.contributor.authorTzagarakis, C
dc.contributor.authorRogers, RD
dc.contributor.authorGeddes, JR
dc.contributor.authorGoodwin, GM
dc.date.accessioned2024-07-18T12:08:39Z
dc.date.available2024-07-18T12:08:39Z
dc.description.abstractObjective: An association between bipolar disorder and cognitive impairment has repeatedly been described, even for euthymic patients. Findings are inconsistent both across primary studies and previous meta-analyses. This study reanalysed 31 primary data sets as a single large sample (N = 2876) to provide a more definitive view. Method: Individual patient and control data were obtained from original authors for 11 measures from four common neuropsychological tests: California or Rey Verbal Learning Task (VLT), Trail Making Test (TMT), Digit Span and/or Wisconsin Card Sorting Task. Results: Impairments were found for all 11 test-measures in the bipolar group after controlling for age, IQ and gender (Ps <= 0.001, E.S. = 0.26-0.63). Residual mood symptoms confound this result but cannot account for the effect sizes found. Impairments also seem unrelated to drug treatment. Some test-measures were weakly correlated with illness severity measures suggesting that some impairments may track illness progression. Conclusion: This reanalysis supports VLT, Digit Span and TMT as robust measures of cognitive impairments in bipolar disorder patients. The heterogeneity of some test results explains previous differences in meta-analyses. Better controlling for confounds suggests deficits may be smaller than previously reported but should be tracked longitudinally across illness progression and treatment.
dc.identifier.issn0001-690X
dc.identifier.other1600-0447
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/11027
dc.language.isoEnglish
dc.publisherWILEY
dc.subjectNEUROCOGNITIVE IMPAIRMENT
dc.subjectWORKING-MEMORY
dc.subjectVERBAL MEMORY
dc.subjectRATING-SCALE
dc.subjectI DISORDER
dc.subjectDEFICITS
dc.subjectLITHIUM
dc.subjectSCHIZOPHRENIA
dc.subjectASSOCIATION
dc.subjectRELIABILITY
dc.titleNeuropsychological testing of cognitive impairment in euthymic bipolar disorder: an individual patient data meta-analysis
dc.typeArticle

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