The effect of a single dose of Mk-801 use on adult brain tissue after an experimental head trauma model applied in immature rats
| dc.contributor.author | Çiğel A. | |
| dc.contributor.author | Sayın O. | |
| dc.contributor.author | Gürgen S.G. | |
| dc.contributor.author | Sönmez A. | |
| dc.date.accessioned | 2025-04-10T11:01:47Z | |
| dc.date.available | 2025-04-10T11:01:47Z | |
| dc.date.issued | 2025 | |
| dc.description.abstract | Objective: Within the scope of this research, the long-term effects of experimental blunt head trauma on immature rats and MK-801 administered acutely after trauma on the brain tissue will be examined. In addition, the impact of trauma and MK-801 on Nestin and CD133, which are essential stem cells, will be evaluated by immunohistochemical and ELISA methods. Methods: In this study, the contusion trauma model was used. Sprague Dawley rats 30 7-day-old were divided into three groups: Group 1 (n = 10) control group, Group 2 (n = 10) trauma Group (head trauma applied), and Group 3 (n = 10) MK-801 + trauma Group. In the third group, immediately after head trauma, MK-801 (Sigma M107) dissolved in physiological saline was administered as a single dose of 1 mg/kg ip. Results: The concentration of nestin was significantly higher in the control group compared to both the trauma and trauma+drug groups (p < 0.001). CD133 was statistically significantly higher in the control group compared to the other two groups (p = 0.002). It was determined that the differences in Nestin CA1 and DG measurements resulted from the trauma and control and trauma and trauma+drug groups, and the differences in CD133 CA1 and DG measurements resulted from the trauma and control group. Conclusion: The positive effect of MK-801 on neuroprotective and neuronal proliferation was elaborated. Administration of MK-801 significantly induced nestin and CD133 concentrations in the injured tissue. © 2025 Informa UK Limited, trading as Taylor & Francis Group. | |
| dc.identifier.DOI-ID | 10.1080/01616412.2024.2448633 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/43650 | |
| dc.publisher | Taylor and Francis Ltd. | |
| dc.title | The effect of a single dose of Mk-801 use on adult brain tissue after an experimental head trauma model applied in immature rats | |
| dc.type | Article |