Acute Spiral Ganglion Cell Degeneration following Acoustic Overstimulation: An Experimental Study

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dc.contributor.authorEskiizmir, G
dc.contributor.authorYücetürk, AV
dc.contributor.authorInan, S
dc.contributor.authorGürgen, SG
dc.date.accessioned2024-07-18T11:40:27Z
dc.date.available2024-07-18T11:40:27Z
dc.description.abstractBackground: To evaluate acoustic overstimulation-induced spiral ganglion cell (SGC) degeneration, and determine the relationship between the duration of acoustic overstimulation and rate of SGC degeneration. Methods: Fifteen guinea pigs were randomized equally to 4 experimental groups, which were exposed to different durations (7.5, 15,30 and 60 min) of acoustic overstimulation (120 dB at 4 kHz), and a control group. Every bulla was examined histopathologically and immunohistochemically. A quantitative and statistical analysis of acidophilic and TUNEL-positive SGCs was performed. Results: In the control group, 2.1% of SGCs were acidophilic and no TUNEL-positive SGC was detected. In contrast, a statistically significant number of acidophilic (p = 0.000) and TUNEL-positive SGCs (p = 0.002) was determined in the experimental groups. Moreover, a positive correlation between the duration of acoustic overstimulation and acidophilic SGCs (p = 0.000), and a statistically significant relationship between the duration of acoustic overstimulation and TUNEL-positive SGCs (p = 0.000) were demonstrated. Conclusion: Acoustic overstimulation may induce acute SGC degeneration. A positive correlation was determined between the duration of acoustic overstimulation and rate of degenerated SGCs. Copyright (C) 2010 S. Karger AG, Basel
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/2430
dc.language.isoEnglish
dc.publisherKARGER
dc.subjectGUINEA-PIG COCHLEA
dc.subjectNOISE EXPOSURE
dc.subjectINTENSE NOISE
dc.subjectIN-SITU
dc.subjectAPOPTOSIS
dc.subjectTRAUMA
dc.subjectSYSTEM
dc.titleAcute Spiral Ganglion Cell Degeneration following Acoustic Overstimulation: An Experimental Study
dc.typeArticle

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