The Role of Transforming Growth Factor Beta and Smad Receptors in Determining Prognosis in High-Grade Primary Brain Tumors: Glioblastoma Multiforme

Simple item page
dc.contributor.authorGürsoy, G
dc.contributor.authorBarutçuoglu, M
dc.contributor.authorSivrikoz, ON
dc.contributor.authorGökalp, S
dc.contributor.authorVatansever, S
dc.date.accessioned2024-07-18T12:03:41Z
dc.date.available2024-07-18T12:03:41Z
dc.description.abstractIntroduction High-grade primary brain tumors cause serious morbidity and mortality. This study aimed to investigate the role of transforming growth factor beta (TGF-beta) and suppressor of mothers against decapentaplegic (Smad) receptors in high-grade primary brain tumors. \Material and Method Thirteen patients with a pathological diagnosis of glioblastoma multiforme were included in the study. Pathological preparations of each patient were analyzed retrospectively in histochemistry and immunohistochemistry laboratories. Transforming growth factor beta 1, TGF-beta 2, TGF-beta 3, Smad 1/2/3, Smad 6, and Smad 7 stainings were evaluated, and the immunoreactivity densities were examined. Result We found out an increase in the expression of TGF-beta 1 and TGF-beta 3 protein. Regarding the inhibitin receptors, Smad 6 showed much more expression than Smad 7. Thus, we found that Smad 6 has a protective effect and role in the tissue. Immunhistochemically, TGF-beta family stains, which are activated by types I-and -II receptors, and the stainless staining of the Smad family might also be showing that the TGF-beta family is taking action with a secondary pathway other than the Smad family. Conclusion In addition to Smad family receptors, Shc-GBR2, SARA, and Ras-Erk1/2 receptors should be investigated in future research. After that, the prognosis, diagnosis, and patient-based chemotherapy strategies for the treatment of glioblastoma multiforme may take a more prominent role.
dc.identifier.issn0103-5355
dc.identifier.other2359-5922
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/9275
dc.language.isoEnglish
dc.publisherGEORG THIEME VERLAG KG
dc.subjectS-PHASE FRACTION
dc.subjectTGF-BETA
dc.subjectCANCER
dc.subjectKI-67
dc.titleThe Role of Transforming Growth Factor Beta and Smad Receptors in Determining Prognosis in High-Grade Primary Brain Tumors: Glioblastoma Multiforme
dc.typeArticle

Files

Collections

Web of Science Koleksiyonu