The effect of dietary and topical celecoxib on 4-nitroquinoline-1-oxide- induced lingual epithelium alternations in rat

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dc.contributor.authorSohrabi M.
dc.contributor.authorSoleimani J.
dc.contributor.authorRoshangar L.
dc.contributor.authorVatansever S.
dc.contributor.authorArbabi F.
dc.contributor.authorKhaki A.A.
dc.contributor.authorAbbasi M.M.
dc.contributor.authorDustar Y.
dc.contributor.authorJavadzadeh Y.
dc.date.accessioned2024-07-22T08:21:24Z
dc.date.available2024-07-22T08:21:24Z
dc.date.issued2009
dc.description.abstractObjective: To compare the preventive effect of dietary and topical Celecoxib (CCB), a potent inhibitor of COX-2 on 4-NQO-induced tongue SCC in rat. Methods: Fifty male Sprague Dawley adult 3- 3.5 months old rats were used as animal model in this study. The tongue SCC was induced by a daily administration of 30 ppm 4-NQO, in drinking water, for 8 months. The rats in case groups received dietary or topical CCB. Tongue Specimens were prepared for histopathological and immunohistochemical (Ki-67) staining and or TUNEL assay were examined. Values are expressed as mean ± SEM and analyzed with Npar Kruscal Wallis and one-way ANOVA tests. p < 0.05 was considered significant. Results: The incidence of tongue precancer lesions, judged by morphological and morhometrical criteria and apoptosis/proliferation ratio, was significantly (p<0.01) reduced by CCB. The effect of topical CCB use, at high doses, was comparable to the effect of dietary CCB. Conclusion: Both topical and dietary CCB have inhibitory effect on 4-NQO induced SCC on tongue. The effect of CCB is probably mediated by suppression of cell proliferation and induction of apoptosis.
dc.identifier.issn00309982
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18578
dc.language.isoEnglish
dc.subject4-Nitroquinoline-1-oxide
dc.subjectAdministration, Topical
dc.subjectAnalysis of Variance
dc.subjectAnimals
dc.subjectCyclooxygenase Inhibitors
dc.subjectDiet
dc.subjectDisease Models, Animal
dc.subjectIn Situ Nick-End Labeling
dc.subjectMale
dc.subjectPrecancerous Conditions
dc.subjectPyrazoles
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectSulfonamides
dc.subjectTongue
dc.subjectTongue Neoplasms
dc.subject4 nitroquinoline 1 oxide
dc.subjectcelecoxib
dc.subjectdrinking water
dc.subjectaged
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectapoptosis
dc.subjectarticle
dc.subjectcancer incidence
dc.subjectcell proliferation
dc.subjectcontrolled study
dc.subjectdrug effect
dc.subjectfluid intake
dc.subjectfood intake
dc.subjecthistopathology
dc.subjectimmunohistochemistry
dc.subjectmale
dc.subjectnick end labeling
dc.subjectnonhuman
dc.subjectrat
dc.subjectscanning electron microscopy
dc.subjecttongue carcinoma
dc.titleThe effect of dietary and topical celecoxib on 4-nitroquinoline-1-oxide- induced lingual epithelium alternations in rat
dc.typeArticle

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