The Functions of PPARs in Aging and Longevity

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dc.contributor.authorErol, A
dc.date.accessioned2024-07-18T11:51:30Z
dc.date.available2024-07-18T11:51:30Z
dc.description.abstractPeroxisome proliferator-activated receptors (PPARs) are key regulators in various age-associated pathophysiological processes related to energy metabolism and oxidative stress. A progressive rise of oxidative stress and related inflammatory reaction appears the hallmarks of the aging process and many age-related diseases. PPARs are important redox-sensitive transcription factors and their dyregulated activations seem to be major culprits for these pathological processes. Drugs targeting PPARs activity are already in widespread clinical use; however, based on these concepts, this review highlights the understanding of the role of PPARs in aging and indicates the necessary particular attention for the potential therapeutic uses of current PPAR agonists in age-associated diseases. Copyright (C) 2007 Adnan Erol. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.identifier.issn1687-4757
dc.identifier.other1687-4765
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/4923
dc.language.isoEnglish
dc.publisherHINDAWI LTD
dc.subjectACTIVATED-RECEPTOR-GAMMA
dc.subjectOXIDATIVE STRESS
dc.subjectCALORIC RESTRICTION
dc.subjectINSULIN-RESISTANCE
dc.subjectSKELETAL-MUSCLE
dc.subjectDIFFERENTIAL EXPRESSION
dc.subjectGENE-EXPRESSION
dc.subjectTISSUE DISTRIBUTION
dc.subjectADIPOSE-TISSUE
dc.subjectFATTY-ACIDS
dc.titleThe Functions of PPARs in Aging and Longevity
dc.typeReview

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