Targeting apoptosis in the hormone- and drug-resistant prostate cancer cell line, DU-145, by gossypol/zoledronic acid combination

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dc.contributor.authorSanli, UA
dc.contributor.authorGorumlu, G
dc.contributor.authorErten, C
dc.contributor.authorGul, MK
dc.contributor.authorCengiz, E
dc.contributor.authorKucukzeybek, Y
dc.contributor.authorKaraca, B
dc.contributor.authorAtmaca, H
dc.contributor.authorUzunoglu, S
dc.contributor.authorKarabulut, B
dc.contributor.authorUslu, R
dc.date.accessioned2024-07-18T12:01:08Z
dc.date.available2024-07-18T12:01:08Z
dc.description.abstractPossible synergistic cytotoxic and apoptotic effects of gossypol with zoledronic acid on DU-145 cells were explored, along with the rationale behind any observed synergism due to the different apoptotic proteins involved. XTT cell proliferation assay was used to assess the cytotoxicity, and DNA fragmentation and caspase 3/7 activity were measured to verify apoptosis. Human Apoptosis Array was used to evaluate apoptotic proteins. The synergistic cytotoxic combination treatment had a versatile effect on apoptotic proteins, through inhibition of anti-apoptotic proteins (including cIAP-1, cIAP-2, survivin, livin, claspin, p53, p21, PON-2 and heat shock proteins) and concurrently the induction of pro-apoptotic proteins (Bad, Bax, Fas, FADD, cleaved caspase-3 and p27). Both drugs had a minimal toxicity profile comparing to cytotoxic agents. Combination treatments targeting many pivotal apoptosis-related proteins may be a rationale option for treatment of prostate cancer. (C) 2009 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.
dc.identifier.issn1065-6995
dc.identifier.other1095-8355
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/8209
dc.language.isoEnglish
dc.publisherWILEY
dc.subjectP53
dc.subjectDEATH
dc.subjectBCL-2
dc.subjectBISPHOSPHONATES
dc.subjectSURVIVIN
dc.subjectGOSSYPOL
dc.subject(-)-GOSSYPOL
dc.subjectTHERAPY
dc.subjectGROWTH
dc.subjectGENE
dc.titleTargeting apoptosis in the hormone- and drug-resistant prostate cancer cell line, DU-145, by gossypol/zoledronic acid combination
dc.typeArticle

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