No pituitary gland volume change in medication-free depressed patients
No Thumbnail Available
Date
2008
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Increased serum cortisol levels and a hyperactive hypothalamo-pituitary-adrenal (HPA) axis have been proposed to play an important role in the pathophysiology of Major Depressive Disorder (MDD). However, there are inconsistent results regarding pituitary gland volume (PGV), which is one of the key elements of the HPA axis evaluated by MRI in depressed patients. In this study, we analyzed the PGV of medication-free moderately depressed MDD patients (N = 34) and age and sex matched healthy controls (N = 39). PGV did not differ between MDD patients and healthy controls [mean volume ± S.D.; 0.76 ± 0.17 cm3 and 0.75 ± 0.14 cm3; ANCOVA, F1,69 = 1.25 p > 0.05; respectively]. Our results confirm that volumetric PGV changes are not crucial for depression pathophysiology among unmedicated, moderately depressed adults. © 2008 Elsevier Inc. All rights reserved.
Description
Keywords
Adult , Analysis of Variance , Case-Control Studies , Chi-Square Distribution , Depressive Disorder, Major , Female , Humans , Magnetic Resonance Imaging , Male , Middle Aged , Pituitary Gland , hydrocortisone , adult , age distribution , article , clinical article , controlled study , demography , disease duration , female , Hamilton scale , human , hypophysis , hypothalamus hypophysis adrenal system , image analysis , major depression , male , neuroimaging , nuclear magnetic resonance imaging , onset age , sex difference , statistical analysis , volumetry