No pituitary gland volume change in medication-free depressed patients

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dc.contributor.authorEker C.
dc.contributor.authorOvali G.Y.
dc.contributor.authorOzan E.
dc.contributor.authorEker O.D.
dc.contributor.authorKitis O.
dc.contributor.authorCoburn K.
dc.contributor.authorGonul A.S.
dc.date.accessioned2024-07-22T08:22:09Z
dc.date.available2024-07-22T08:22:09Z
dc.date.issued2008
dc.description.abstractIncreased serum cortisol levels and a hyperactive hypothalamo-pituitary-adrenal (HPA) axis have been proposed to play an important role in the pathophysiology of Major Depressive Disorder (MDD). However, there are inconsistent results regarding pituitary gland volume (PGV), which is one of the key elements of the HPA axis evaluated by MRI in depressed patients. In this study, we analyzed the PGV of medication-free moderately depressed MDD patients (N = 34) and age and sex matched healthy controls (N = 39). PGV did not differ between MDD patients and healthy controls [mean volume ± S.D.; 0.76 ± 0.17 cm3 and 0.75 ± 0.14 cm3; ANCOVA, F1,69 = 1.25 p > 0.05; respectively]. Our results confirm that volumetric PGV changes are not crucial for depression pathophysiology among unmedicated, moderately depressed adults. © 2008 Elsevier Inc. All rights reserved.
dc.identifier.DOI-ID10.1016/j.pnpbp.2008.05.023
dc.identifier.issn02785846
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18956
dc.language.isoEnglish
dc.subjectAdult
dc.subjectAnalysis of Variance
dc.subjectCase-Control Studies
dc.subjectChi-Square Distribution
dc.subjectDepressive Disorder, Major
dc.subjectFemale
dc.subjectHumans
dc.subjectMagnetic Resonance Imaging
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPituitary Gland
dc.subjecthydrocortisone
dc.subjectadult
dc.subjectage distribution
dc.subjectarticle
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectdemography
dc.subjectdisease duration
dc.subjectfemale
dc.subjectHamilton scale
dc.subjecthuman
dc.subjecthypophysis
dc.subjecthypothalamus hypophysis adrenal system
dc.subjectimage analysis
dc.subjectmajor depression
dc.subjectmale
dc.subjectneuroimaging
dc.subjectnuclear magnetic resonance imaging
dc.subjectonset age
dc.subjectsex difference
dc.subjectstatistical analysis
dc.subjectvolumetry
dc.titleNo pituitary gland volume change in medication-free depressed patients
dc.typeArticle

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