Prenatal administration of granulocyte-macrophage colony-stimulating factor increases mesenchymal vascular endothelial growth factor expression and maturation in fetal rat lung
| dc.contributor.author | Yuksel H. | |
| dc.contributor.author | Yilmaz O. | |
| dc.contributor.author | Baytur Y.B. | |
| dc.contributor.author | Ozbilgin K. | |
| dc.date.accessioned | 2025-04-10T11:16:21Z | |
| dc.date.available | 2025-04-10T11:16:21Z | |
| dc.date.issued | 2008 | |
| dc.description.abstract | The aim of this study was to determine influence of prenatal granulocyte-macrophage colony-stimulating factor (GM-CSF) administration on lung growth, maturation, and vascular endothelial growth factor (VEGF) expression. Twenty Wistar rats received sterile saline (1 mL) or recombinant human GM-CSF (50 μg/kg) on day 16 of pregnancy. Rats were sacrificed on days 18 and 20 of gestation. H-score for VEGF was calculated immunohistochemically. Alveolar VEGF expression on days 18 and 20 of gestation was significantly higher in the GM-CSF group (P <.01). Increase in VEGF with prenatal GM-CSF administration indicates that GM-CSF may stimulate lung growth and maturation and may be protective against lung disease due to prematurity. Copyright © Informa Healthcare USA, Inc. | |
| dc.identifier.DOI-ID | 10.1080/01902140802341736 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/51746 | |
| dc.title | Prenatal administration of granulocyte-macrophage colony-stimulating factor increases mesenchymal vascular endothelial growth factor expression and maturation in fetal rat lung | |
| dc.type | Article |