TGF-βs and SMADs Activities at the Site of Failed Neural Tube in the Human Embryos

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dc.contributor.authorBarutcuoglu, M
dc.contributor.authorUmur, AS
dc.contributor.authorVatansever, HS
dc.contributor.authorUmur, N
dc.contributor.authorOzbilgin, K
dc.contributor.authorSayhan, S
dc.contributor.authorSelcuki, M
dc.date.accessioned2024-07-18T11:53:58Z
dc.date.available2024-07-18T11:53:58Z
dc.description.abstractAIM: Transforming growth factor beta (TGF-beta) and Smads control intracellular signaling pathways in neurulation. Although previously reported similar experimental animal studies, the aim of this human study is to investigate the expression of TGF-beta (1,2,3) and Smads (1,2,3,6,7) in aborted human fetuses with myeloschisis. MATERIAL and METHODS: Twelve human fetuses with neural tube defect were obtained. They were stained with antibodies against TGF-beta 1, TGF-beta 2,TGF-beta 3, Smad (1,2,3), Smad 6 and Smad 7 using the indirect immunohistochemical technique. RESULTS: We noted mild immune reactivity of TGF-beta 1 and TGF-beta 2 in the open neural plate, motor neurons and surrounding tissue. Strong immune reactivity of TGF-beta 3 was shown in only open neural plate and surrounding tissue. Immunoreactivity of all Smads noted negative except Smad7. CONCLUSION: These results suggested at the site where the neural tube failed to close, TGF-beta 1,2 and Smads 1,2,3,6 do not continue their activity and decrease with internal timing of embryonic development. Additionally ectodermal layers are considered by embryo asnot closed wound and TGF-beta 3 activity may be an effort to repair the failed closure.
dc.identifier.issn1019-5149
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/6011
dc.language.isoEnglish
dc.publisherTURKISH NEUROSURGICAL SOC
dc.subjectGROWTH-FACTOR-BETA
dc.subjectNERVOUS-SYSTEM
dc.subjectFAMILY-MEMBERS
dc.subjectSPINAL-CORD
dc.subjectDIFFERENTIATION
dc.subjectLOCALIZATION
dc.subjectEXPRESSION
dc.subjectROLES
dc.subjectNEURULATION
dc.subjectMECHANISMS
dc.titleTGF-βs and SMADs Activities at the Site of Failed Neural Tube in the Human Embryos
dc.typeArticle

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