The effect of anti-tumor necrosis factor (TNF)-alpha therapy with etanercept on endothelial functions in patients with rheumatoid arthritis

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dc.contributor.authorTikiz, H
dc.contributor.authorArslan, Ö
dc.contributor.authorPirildar, T
dc.contributor.authorTikiz, C
dc.contributor.authorBayindir, P
dc.date.accessioned2024-07-18T12:02:35Z
dc.date.available2024-07-18T12:02:35Z
dc.description.abstractObjective: To investigate the effects of tumor necrosis factor (INF)-alpha antagonism with etanercept (ENC) on endothelial functions in patients with active rheumatoid arthritis (RA). Methods: A total of 21 patients with RA were enrolled in this prospective study. Eleven of them (8 women, 3 men mean age 47.0 +/- 10.1 years) with high disease activity despite the conventional treatment were assigned to Group 1 and were given ENC treatment twice a week (25 mg SC injection) for 12 weeks. Ten patients with RA (8 women, 2 men mean age 55.0 +/- 6.4 years) under conventional methotrexate and prednisone therapy were assigned as Control group (Group 2). Endothelium-dependent and -independent vasodilator responses of the brachial artery were assessed by high-resolution ultrasound. Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were also measured at baseline and at the post treatment period. Mann-Whitney U and Wilcoxon tests were used to compare the data and correlation analysis was performed using Pearson correlation test. Results: Endothelium-dependent vasodilatation improved from 5.2 +/- 0.8% to 7.9 +/- 1.3% (p=0.04) in ENC group, while no significant change was observed in the control group (from 6.6 +/- 1.1% to 7.0 +/- 1.8% p=0.67). No significant changes were found in endothelium-independent vasodilatation and baseline brachial artery diameters in both groups. A significant reduction in ESR and CRP were observed in patients receiving ENC (from 16.2 +/- 6.8 to 9.2 +/- 5.1 mm/h, p=0.003 and from 14.68 +/- 3.4 to 9.25 +/- 3.7 mg/L, p=0.003, respectively). Conclusion: Treatment with ENC for 12 weeks significantly improved endothelial function in patients with active RA compared to those under conventional therapy. The findings of the present study support the hypothesis that the use of TNF-alpha blockers in patients with active RA may reduce the high incidence of cardiovascular complications. (Anadolu Kardiyol Derg 2010; 10: 98-103)
dc.identifier.issn2149-2263
dc.identifier.other2149-2271
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/8546
dc.language.isoEnglish
dc.publisherTURKISH SOC CARDIOLOGY
dc.subjectRISK-FACTORS
dc.subjectDISEASE-ACTIVITY
dc.subjectIN-VIVO
dc.subjectDYSFUNCTION
dc.subjectATHEROSCLEROSIS
dc.subjectMETHOTREXATE
dc.subjectMORTALITY
dc.titleThe effect of anti-tumor necrosis factor (TNF)-alpha therapy with etanercept on endothelial functions in patients with rheumatoid arthritis
dc.typeArticle

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