Synthesis of Cycloalk[b]indole Bearing Spiropiperidine Derivatives
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Date
2016
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Abstract
(Chemical Equation Presented) The novel heterocyclic compounds that have cycloalk[b]indole moiety bearing spiropiperidinone and spiropiperidinedione (3a, 3b, 3c, 5a, 5b, 8a, 8b, and 10a) were synthesized for the first time. The synthesis of spiropiperidinone and spiropiperidinedione structures was performed by a new method. These compounds are similar to sedative and hypnotic drugs such as methyprylon, glutethimide, and thalidomide. © 2015 HeteroCorporation.
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4 methyl 1h spiro[cyclopenta[b]indole 2,3' piperidine] 1,2'(3h,4h)dione , 4 methyl 1h spiro[cyclopenta[b]indole 2,3' piperidine] 1,2',6' (3h,4h)trione , 4 methyl 1h spiro[cyclopenta[b]indole 2,3' piperidine] 2',3 (4h)dione , 4 methyl 1h spiro[cyclopenta[b]indole- 2,3' piperidine] 2',3,6' (4h)trione , 5 methyl 7,8 dihydro 5h spiro[cyclohepta[b]indole 9,3' piperidine] 2',6',10(6h)trione , 9 methyl 1,2 dihydrospiro[carbazole 3,3' piperidine] 2',4 (9h)dione , 9 methyl 1,2 dihydrospiro[carbazole 3,3' piperidine] 2',4,6' (9h)trione , 9,9' dimethyl 3, 4, 3', 4', di dihydrospiro[bicarbazole 2,3',2',3''dipiperidine] 1,2',6',1',2'',6''(9h,9'h)hexaone , cycloalk[b]indole derivative , glutethimide , heterocyclic compound , indole derivative , methyl 2 (2 cyanoethyl) 4 methyl 1 oxo 1,2,3,4 tetrahydrocyclopenta[b]indole 2 carboxylate , methyl 3 (2 cyanoethyl) 9 methyl 4 oxo 2,3,4,9 tetrahydro 1h carbazole 3 carboxylate , methyl 4 methyl 1 oxo 1,2,3,4 tetrahydrocyclopenta[b]indole 2 carboxylate , methyl 5 methyl 10 oxo 5,6,7,8,9,10 hexahydrocyclohepta[b]indole 9 carboxylate , methyl 5 methyl 6 oxo 5,6,7,8,9,10 hexahydrocyclohepta[b]indole 7 carboxylate , methyl 7 (2 cyanoethyl) 5 methyl 6 oxo 5,6,7,8,9,10 hexahydrocyclohepta[b]indole 7 carboxylate , methyl 9 (2 cyanoethyl) 5 methyl 10 oxo 5,6,7,8,9,10 hexahydrocyclohepta[b]indole 9 carboxylate , methyl 9 methyl 4 oxo 2,3,4,9 tetrahydro 1h carbazole 3 carboxylate , methyprylon , piperidine derivative , spiropiperidine derivative , spiropiperidinedione derivative , thalidomide , unclassified drug , analytic method , Article , biological activity , chemical analysis , chemical reaction , drug structure , drug synthesis , polymerization , structure analysis