Molecular Diversity of Drug Resistant Mycobacterium Tuberculosis Strains in Western Turkey

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dc.contributor.authorSürücüoglu, S
dc.contributor.authorGünal, S
dc.contributor.authorÖzkütük, N
dc.contributor.authorBiçmen, C
dc.contributor.authorÖzsöz, A
dc.contributor.authorGazi, H
dc.contributor.authorDurmaz, R
dc.date.accessioned2024-07-18T12:02:53Z
dc.date.available2024-07-18T12:02:53Z
dc.description.abstractObjective: The aim of this study was to investigate the molecular diversity and clonal relationship of drug resistant Mycobacterium tuberculosis strains isolated in Western Turkey. Materials and Methods: A total of 87 strains isolated between 2006 and 2009, eight of which were rifampicin monoresistant and 79 were multidrug resistant, were analyzed with IS6110 RFLP and spoligotyping methods. Results: The results of spoligotyping showed that 7% of the strains were orphans, and 8% were undefined for family in the SpolDB4 database. Major families of the strains were LAM (38%), T (35%), Haarlem (7%), Beijing (2%), S (2%) and U (1%) families. The clustering rate by spoligotyping was calculated as 75%. The most predominant SIT cluster was SIT41 (29%). According to the results of IS6110 RFLP, 71 different patterns of IS6110 were observed. Low copy number was found in 26% of the strains. When the results of two methods were combined, the final clustering rate was calculated as 26%. Conclusions: The genotypical distribution of drug resistant tuberculosis isolates in our region indicates genetic diversity and the clustering rate was found low in our region. However, more comprehensive and long-term molecular epidemiological studies are needed to control the drug resistant strains.
dc.identifier.issn2146-3123
dc.identifier.other2146-3131
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/8756
dc.language.isoEnglish
dc.publisherGALENOS PUBL HOUSE
dc.subjectGENETIC DIVERSITY
dc.subjectEPIDEMIOLOGY
dc.subjectSPREAD
dc.titleMolecular Diversity of Drug Resistant Mycobacterium Tuberculosis Strains in Western Turkey
dc.typeArticle

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