Antileishmanial Activity of Selected Turkish Medicinal Plants

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dc.contributor.authorOzbilgin, A
dc.contributor.authorDurmuskahya, C
dc.contributor.authorKayalar, H
dc.contributor.authorErtabaklar, H
dc.contributor.authorGunduz, C
dc.contributor.authorUral, IO
dc.contributor.authorZeyrek, F
dc.contributor.authorKurt, O
dc.contributor.authorCavus, I
dc.contributor.authorBalcioglu, C
dc.contributor.authorToz, SO
dc.contributor.authorOzbel, Y
dc.date.accessioned2024-07-18T12:06:28Z
dc.date.available2024-07-18T12:06:28Z
dc.description.abstractPurpose: To determine the in vitro and in vivo anti-leishmanial activities of extracts obtained from Centaurea calolepis, Phlomis lycia, Eryngium thorifolium, Origanum sipyleum and Galium incanum ssp. centrale. Methods: To estimate the cytotoxicity of plant extracts, WST-1 assay was used. Parasite inhibition in the presence of plant extracts (25 - 500 mu g/ml) in comparision with control group and reference group (glucantime, 25 mu g/ml) at 12 - 72 h were determined in vitro on L. tropica promastigotes. The in vivo leishmanicidal activity of the extracts was evaluated against L. tropica-infected mice with glucantime as reference drug. Results: The chloroform extract of Galium incanum ssp. centrale showed the highest cytotoxicity with IC50 value of 0.0316 +/- 0.005 mu g/ml. In vitro parasite inhibition by the plant extracts ranged between 16.7 +/- 0.01 % and 100 +/- 0.00 % at 25 mu g/ml concentration. The methanol extract of Eryngium thorifolium possessed the highest activity on promastigotes of L. tropica with 100 % inhibition at 25 mu g/ml. The water and chloroform extracts of C. calolepis and water and methanol extracts of E. thorifolium at a dose of 100 mg/kg reduced parasitaemia in L. tropica infected mice. Conclusion: Parasite viability results suggest that the methanol extract of Eryngium thorifolium, regarded as non-cytotoxic, is a promising candidate drug for treating L. tropica infection.
dc.identifier.issn1596-5996
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/10418
dc.language.isoEnglish
dc.publisherPHARMACOTHERAPY GROUP
dc.subjectIN-VITRO
dc.subjectLEISHMANIA-MAJOR
dc.subjectNATURAL-PRODUCTS
dc.subjectANTIPROTOZOAL
dc.subjectANTIMALARIAL
dc.subjectFLAVONOIDS
dc.subjectINHIBITION
dc.subjectGLYCOSIDES
dc.subjectEXTRACTS
dc.subjectL.
dc.titleAntileishmanial Activity of Selected Turkish Medicinal Plants
dc.typeArticle

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