Docetaxel/zoledronic acid combination triggers apoptosis synergistically through downregulating antiapoptotic Bcl-2 protein level in hormone-refractory prostate cancer cells

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dc.contributor.authorKarabulut, B
dc.contributor.authorErten, C
dc.contributor.authorGul, MK
dc.contributor.authorCengiz, E
dc.contributor.authorKaraca, B
dc.contributor.authorKucukzeybek, Y
dc.contributor.authorGorumlu, G
dc.contributor.authorAtmaca, H
dc.contributor.authorUzunoglu, S
dc.contributor.authorSanli, UA
dc.contributor.authorBaran, Y
dc.contributor.authorUslu, R
dc.date.accessioned2024-07-18T12:05:06Z
dc.date.available2024-07-18T12:05:06Z
dc.description.abstractDocetaxel, a semi-synthetic taxane analogue, is used effectively in the treatment of metastatic prostate cancer. Zoledronic acid, the most potent member of bisphosphonates, has shown pleiotropic anti-tumoral effects on prostate cancer cells. We have explored the possible additive/synergistic effects and the apoptotic pathways induced by combination treatment of docetaxel and zoledronic acid in hormone and drug refractory, PC-3 and DU-145 prostate cancer cells. Combination of docetaxel and zoledronic acid synergistically inhibits cell growth in PC-3 and DU-145 cells. Moreover, this effect was due to downregulation of antiapoptotic protein Bcl-2 in PC-3 and DU-145 cells. In conclusion, docetaxel/zoledronic acid combination is potentially a novel and effective approach for the treatment of prostate cancer. (C) 2008 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.
dc.identifier.issn1065-6995
dc.identifier.other1095-8355
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/9541
dc.language.isoEnglish
dc.publisherWILEY
dc.subjectZOLEDRONIC ACID
dc.subjectBISPHOSPHONATES
dc.subjectPROGRESSION
dc.subjectGROWTH
dc.subjectMARKER
dc.titleDocetaxel/zoledronic acid combination triggers apoptosis synergistically through downregulating antiapoptotic Bcl-2 protein level in hormone-refractory prostate cancer cells
dc.typeArticle

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