Dickkopf-1 levels in Turkish patients with bladder cancer and its association with clinicopathological features

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dc.contributor.authorKaba M.
dc.contributor.authorPirincci N.
dc.contributor.authorBenli E.
dc.contributor.authorGecit I.
dc.contributor.authorGunes M.
dc.contributor.authorYuksel M.B.
dc.contributor.authorTok A.
dc.contributor.authorKemik A.S.
dc.date.accessioned2025-04-10T11:13:16Z
dc.date.available2025-04-10T11:13:16Z
dc.date.issued2014
dc.description.abstractBackground: Evidence indicates that Dickkopf-1 (DKK-1) levels may be a biomarker for cancer risk. The aim of this study was to assess DKK-1 and its correlation with clinic-pathological features in patients with bladder cancer. Materials and Methods: DKK-1 levels were determined in serum samples from 90 patients with bladder cancer before transurethral tumor resection. The concentrations of DKK-1 were determined by using enzyme linked immune-sorbent assay (ELISA). Results: Elevated preoperative DKK-1 levels were associated with tumor stage (p<0.001), grade (p<0.001) and histological grade (p<0.001). Conclusions: The results of our study demonstrated that the level of serum DKK-1 is correlated with both disease progression and increase in the tumor grade. Preoperative serum DKK-1 elevation may thus represent a novel marker for the determination of bladder cancer and the detection of patients with a likely poor clinical outcome.
dc.identifier.DOI-ID10.7314/APJCP.2014.15.1.381
dc.identifier.urihttp://hdl.handle.net/20.500.14701/49804
dc.publisherAsian Pacific Organization for Cancer Prevention
dc.titleDickkopf-1 levels in Turkish patients with bladder cancer and its association with clinicopathological features
dc.typeArticle

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