Radiosynthesis and biodistribution of 99mTc-Sulfamethoxazole: a novel molecule for in-vivo infection imaging

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dc.contributor.authorUyaroglu, Ö
dc.contributor.authorDemiroglu, H
dc.contributor.authorTopal, G
dc.contributor.authorParlak, Y
dc.contributor.authorGümüser, FG
dc.contributor.authorTürköz, EU
dc.contributor.authorDemir, V
dc.contributor.authorAtes, B
dc.contributor.authorÜnak, P
dc.contributor.authorAvcibasi, U
dc.date.accessioned2024-07-18T12:01:29Z
dc.date.available2024-07-18T12:01:29Z
dc.description.abstractThe aim of this study was to prepare Tc-99m-Sulfamethoxazole complex and evaluate its efficiency as an infection imaging agent. The Sulfamethoxazole was labeled with Tc-99m and its biological efficacy as a potential radio tracer for Staphylococcus aureus infection was investigated in bacterially infected Albino Wistar rats. The radiolabeling yield was found to be 95 +/- 3.07% and remained constant at more than 93 +/- 0.1% even in serum for 240 min after radiolabeling. Tc-99m-Sulfamethoxazole prepared with high yield localized well in the bacterially infected muscle of the rats. Tc-99m-Sulfamethoxazole may be developed as a radiopharmaceutical agent to distinguish infection from inflammation by nuclear imaging.
dc.identifier.issn1054-2523
dc.identifier.other1554-8120
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/8465
dc.language.isoEnglish
dc.publisherSPRINGER BIRKHAUSER
dc.subjectFREEZE-DRIED KITS
dc.subjectANTIMICROBIAL PEPTIDES
dc.subjectBACTERIAL-INFECTIONS
dc.subjectDETECTING SITES
dc.subjectQUALITY-CONTROL
dc.subjectTC-99M-CIPROFLOXACIN
dc.subjectAGENT
dc.subjectRADIOPHARMACEUTICALS
dc.subjectSCINTIGRAPHY
dc.subjectSULFONAMIDE
dc.titleRadiosynthesis and biodistribution of 99mTc-Sulfamethoxazole: a novel molecule for in-vivo infection imaging
dc.typeArticle

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