English
| dc.contributor.author | Bayraktar, S | |
| dc.contributor.author | Hondur, G | |
| dc.contributor.author | Sekeroglu, MA | |
| dc.contributor.author | Oezyurt, BC | |
| dc.contributor.author | Sen, E | |
| dc.date.accessioned | 2024-07-18T11:57:21Z | |
| dc.date.available | 2024-07-18T11:57:21Z | |
| dc.description.abstract | SAGE PUBLICATIONS LTD | |
| dc.identifier.issn | 1724-6016 | |
| dc.identifier.uri | http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/7024 | |
| dc.language.iso | Article; Early Access | |
| dc.publisher | 1120-6721 | |
| dc.subject | Purpose: To investigate the long-term effects of topical latanoprost 0.005% treatment on pupillary functions in early-stage primary open-angle glaucoma (POAG) eyes using automated pupillometry.Methods: This prospective study involved 20 eyes of 20 treatment-naive subjects with early-stage POAG. After comprehensive ophthalmic examination, static and dynamic pupillometry measurements were performedbefore treatment, at the 1st follow-up visit (1.10 +/- 0.30 months) and the 2nd follow-up visit (25.85 +/- 10.26 months) after treatment initiation. Dynamic parameters included resting diameter (mm), amplitude (mm), latency (ms), duration (ms), and velocity (mm/s) of pupil contraction and dilation. Static pupillometry parameters were pupil diameter (PD, mm) in high-photopic, low-photopic, mesopic and scotopic conditions.Results: The velocity of pupil dilation significantly decreased during the 1st visit (p = 0.008) and the 2nd visit (p = 0.0003) of treatment compared to the pre-treatment visit. The resting PD was also significantly higher after the 1st visit (p = 0.003) and the 2nd visit (p = 0.001) compared to the pre-treatment visit. However, the difference in resting PD measured between the 1st and 2nd visits did not reach statistical significance (p = 0.065). There were no significant changes in other dynamic parameters (p > 0.05 for all). Additionally, a mild, but not significant, mydriatic effect was observed in PD measurements under scotopic, mesopic and low photopic lighting conditions after follow-up. None of the static and dynamic parameters correlate with age, changes in intraocular pressure (IOP) or mean deviation (MD) values of visual field tests.Conclusion: The long-term topical latanoprost 0.005% treatment in early-stage POAG has a slight mydriatic effect on the pupil. Further longitudinal clinical studies with larger patient cohorts are necessary to better understand the effects of latanoprost on pupillary functions. | |
| dc.title | English | |
| dc.type | GLAUCOMA | |
| dc.type | PROSTAGLANDIN-F2-ALPHA | |
| dc.type | CONTRACTION | |
| dc.type | DORZOLAMIDE | |
| dc.type | DIAMETER | |
| dc.type | LIGHT | |
| dc.type | SIZE |