Prospective registry of adult patients receiving therapeutic plasma exchange with a presumptive diagnosis of thrombotic microangiopathy (TMA): The Turkish hematology research and education group (ThREG)-TMA02 study

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dc.contributor.authorAkpınar S.
dc.contributor.authorTekgunduz E.
dc.contributor.authorErkurt M.A.
dc.contributor.authorEsen R.
dc.contributor.authorYılmaz M.
dc.contributor.authorKarakus V.
dc.contributor.authorVural F.
dc.contributor.authorGediz F.
dc.contributor.authorAydogdu I.
dc.contributor.authorKaynar L.
dc.contributor.authorKorkmaz S.
dc.contributor.authorGoker H.
dc.contributor.authorKelkitli E.
dc.contributor.authorAyyıldız O.
dc.contributor.authorDemirkan F.
dc.date.accessioned2025-04-10T11:05:54Z
dc.date.available2025-04-10T11:05:54Z
dc.date.issued2021
dc.description.abstractThrombotic microangiopathy(TMA) is a pathological diagnosis characterized by abnormalities of small vessels leading to microvascular thrombosis of arterioles and capillaries. The current prospective, non-interventional, multicenter (n:18) study aimed to define distribution of different TMA forms in adult Turkish patients who were referred for therapeutic plasma exchange (TPE) for a presumptive diagnosis of TMA. Patients with serum ADAMTS13 activity <5% were diagnosed as acquired thrombotic thrombocytopenic purpura (aTTP). Patients presenting with ADAMTS13 activity 6–10 % / normal renal function and patients with ADAMTS13 activity >10 %, normal renal function and no secondary TMA were treated as unclassified TMA. The study included a total of 97 patients (female: 60; male: 30) with a median age of 48 (18−74). Detailed evaluation at 1 month after hospital admission revealed aTTP, secondary TMA, infection/complement-associated hemolytic uremic syndrome and unclassified TMA in 32 (33 %), 33 (34 %), 26 (27 %) and 6 (6%) patients respectively. As subclassification of various TMAs will dictate specific therapy, proper diagnosis in a timely manner is of utmost clinical significance. © 2021 Elsevier Ltd
dc.identifier.DOI-ID10.1016/j.transci.2021.103312
dc.identifier.urihttp://hdl.handle.net/20.500.14701/46337
dc.publisherElsevier Ltd
dc.titleProspective registry of adult patients receiving therapeutic plasma exchange with a presumptive diagnosis of thrombotic microangiopathy (TMA): The Turkish hematology research and education group (ThREG)-TMA02 study
dc.typeArticle

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