Neuroprotective Effects of Oleocanthal, a Compound in Virgin Olive Oil, in a Rat Model of Traumatic Brain Injury

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dc.contributor.authorMete, M
dc.contributor.authorAydemir, I
dc.contributor.authorUnsal, UU
dc.contributor.authorCollu, F
dc.contributor.authorVatandas, G
dc.contributor.authorGurcu, B
dc.contributor.authorDuransoy, YK
dc.contributor.authorTaneli, F
dc.contributor.authorTuglu, MI
dc.contributor.authorSelcuki, M
dc.date.accessioned2024-07-18T12:05:12Z
dc.date.available2024-07-18T12:05:12Z
dc.description.abstractAIM: To evaluate the neuroprotective effects of deocanthal OC in a rat model of traumatic brain injury (TBI). MATERIAL and METHODS: Twenty-six adult male, Wistar albino rats were used. The rats were divided into 4 groups. Group 1 was the sham group (n=5). Group 2 was the trauma group (n=5) where rats were treated with 10 mg/kg saline intraperitoneally (IP) twice a day. Groups 3 and 4, rats were treated with 10 (group 3, n=8) or 30 (group 4, n=8) mg/kg OC IP twice a day. For each group, brain samples were collected 72 hours after injury. Brain samples and blood were evaluated with histopathological and biochemical methods. RESULTS: Histopathological evaluation revealed a significant difference between Group 2 and Group 4. Biochemical findings demonstrated that the oxidative stress index was highest in Group 2 and lowest in Group 4. CONCLUSION: OC has a protective effect on neural cells after TBI. This effect is achieved by reducing oxidative stress and apoptosis.
dc.identifier.issn1019-5149
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/9599
dc.language.isoEnglish
dc.publisherTURKISH NEUROSURGICAL SOC
dc.subjectPATHOPHYSIOLOGY
dc.subjectINHIBITION
dc.titleNeuroprotective Effects of Oleocanthal, a Compound in Virgin Olive Oil, in a Rat Model of Traumatic Brain Injury
dc.typeArticle

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