Comparison of serum neuropeptide-FF and catestatin levels in hypertensive pregnant women
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Abstract
Aim: We aimed to compare the levels of Neuropeptide-FF and Catestatin in the sera of hypertensive and normotensive pregnant women, to determine the possible changes in hypertensive diseases of pregnancy and to examine the possible place of pregnancy in hypertensive diseases. Material and Methods: We used the quantitative analysis method to test the hypotheses of the research and examine the relationship between variables. Neuropeptide FF and Catestatin levels were analyzed by Enzyme Linked Immunoassay (ELISA) method. Neuropeptide-FF and Catestatin values of patient and control groups were analyzed with Mann -Whitney and Chi-square tests. Results: A higher Catestatin value was determined in the patient group compared to the control group, and this difference was statistically significant(p = 0.000). Catestatin value in the patient group was 31.61 +/- 12.54, and value in the control group was 48.46 +/- 22.45 and the relation was statistically found significant (p <0.05). The neuropeptide-FF was not statistically significant in the patient and control group compared to the control group (p = 0.916). Therefore, the Neuropeptide-FF value in the patient group was 134.30 +/- 93.72; this value was found as 139.49 +/- 96.41 in the control group, but the relation statistically was not found significant (p> 0.05). According to the analysis results of our study, a statistically significant difference was found for Catestatin at the 5% significance level between the patient group and the control group. Discussion: Decreased NPFF expression in the hypothalamus of hypertensive patients may lead to impaired interaction with other neurochemical systems and therefore may play a role in the pathogenesis of hypertensive disease.