Examining the protective effects of acetyl l-carnitine on cisplatin-induced uterine tube toxicity

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dc.contributor.authorSaribas G.S.
dc.contributor.authorErdogan D.
dc.contributor.authorGoktas G.
dc.contributor.authorAkyol S.N.
dc.contributor.authorHirfanoglu I.M.
dc.contributor.authorGurgen S.G.
dc.contributor.authorCoskun N.
dc.contributor.authorOzogul C.
dc.date.accessioned2025-04-10T11:09:00Z
dc.date.available2025-04-10T11:09:00Z
dc.date.issued2016
dc.description.abstractThe aim of this study was to investigate the effects of cisplatin and the protective role of acetyl l-carnitine against uterine tube toxicity. Twenty-four female Wistar albino rats were divided into four groups: control group was injected with saline (control); group 2 was injected with acetyl l-carnitine; group 3 was injected with cisplatin; and group 4 was pre-treated with acetyl l-carnitine before cisplatin intraperitoneal injection. According to our results, a significant weight loss was observed in rats from group 3. The thickness of the wall and epithelium of uterine tube were decreased in group 3 rats. We elaborate the protein expression of caspase in epithelium and stroma by IHC. We found that the expression of caspase and the number of TUNEL-positive cells were increased in group 3 rats compared to the other groups. In our study, we showed the protective role of acetyl l-carnitine against uterine tube toxicity caused by cisplatin. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
dc.identifier.DOI-ID10.1080/01443615.2016.1209174
dc.identifier.urihttp://hdl.handle.net/20.500.14701/48421
dc.publisherTaylor and Francis Ltd
dc.titleExamining the protective effects of acetyl l-carnitine on cisplatin-induced uterine tube toxicity
dc.typeArticle

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