Tear function changes of postmenopausal women in response to hormone replacement therapy
| dc.contributor.author | Kuscu N.K. | |
| dc.contributor.author | Toprak A.B. | |
| dc.contributor.author | Vatansever S. | |
| dc.contributor.author | Koyuncu F.M. | |
| dc.contributor.author | Guler C. | |
| dc.date.accessioned | 2025-04-10T11:17:55Z | |
| dc.date.available | 2025-04-10T11:17:55Z | |
| dc.date.issued | 2003 | |
| dc.description.abstract | Objective: The goal of this study was to search the effect of hormone replacement therapy (HRT) on tear function changes in postmenopausal women. Methods: Following initial ophtalmic evaluation and tear sample collection, the subjects were given daily 0.625 mg conjugated estrogen, and either continuous combined or cyclic 5 mg medroxyprogesterone acetate was added. Eye examination included visual acuity, slit-lamp examination, fundus examination, tonometry, Schirmer's test, and break up time (BUT) evaluation. Six months later, control examination was done and repeat tear samples were obtained. Tear immune globulin A (IgA) and lysozyme levels were measured by gel electrophoresis. The pictures of the bands were evaluated by digital image analysis with Scion Image program. Results: Conjunctival vascular congestion, laxity and corneal desquamation did not change before and after HRT (P>0.05). A significant improvement was noted in meibomian gland inflammation (P=0.034). We have not observed any significant difference in burning, foreign body sensation, and tearing (P>0.05). In addition, no significant difference was noted in BUT (P=0.370) and Schirmer's test values (P=0.271). Though both lysozyme and IgA levels were elevated following the therapy, only IgA levels increased significantly (P=0.04). Conclusion: HRT decreased meibomian gland inflammation and increased tear lysozyme and IgA levels in postmenopausal women. © 2002 Elsevier Science Ireland Ltd. All rights reserved. | |
| dc.identifier.DOI-ID | 10.1016/S0378-5122(02)00316-X | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/53035 | |
| dc.title | Tear function changes of postmenopausal women in response to hormone replacement therapy | |
| dc.type | Article |