Changes in the levels of endothelium-derived coagulation parameters in nonalcoholic fatty liver disease

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dc.contributor.authorBilgir, O
dc.contributor.authorBilgir, F
dc.contributor.authorBozkaya, G
dc.contributor.authorCalan, M
dc.date.accessioned2024-07-18T12:02:37Z
dc.date.available2024-07-18T12:02:37Z
dc.description.abstractIn a majority of patients with nonalcoholic fatty liver disease (NAFLD), cardiovascular risk factors including diabetes mellitus type 2, abdominal obesity, and metabolic syndrome are present. The purpose of this study is to investigate the presence of endothelial injury and the changes in coagulation parameters in NAFLD patients. For this purpose, plasma levels of von Willebrand factor (vWF), thrombomodulin, urokinase plasminogen activator (uPA), plasminogen activator inhibitor-1 (PAI-1), and tissue factor pathway inhibitor (TFPI) in patients with NAFLD were measured. There was a significant difference in vWF and TFPI levels between patient and control groups (P < 0.05). However, no statistically significant difference was obtained in PAI-1, uPA, and thrombomodulin levels between the two groups (P > 0.05). According to our results, an increase in vWF and TFPI levels indicates an endothelial injury in NAFLD cases.
dc.identifier.issn0957-5235
dc.identifier.other1473-5733
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/8563
dc.language.isoEnglish
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.subjectFACTOR PATHWAY INHIBITOR
dc.subjectINTERCELLULAR-ADHESION MOLECULE-1
dc.subjectCARDIOVASCULAR RISK-FACTORS
dc.subjectTISSUE FACTOR
dc.subjectINSULIN-RESISTANCE
dc.subjectSTEATOHEPATITIS
dc.subjectATHEROSCLEROSIS
dc.subjectTFPI
dc.subjectMEN
dc.subjectASSOCIATION
dc.titleChanges in the levels of endothelium-derived coagulation parameters in nonalcoholic fatty liver disease
dc.typeArticle

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