Effects of chronic amiodarone treatment on rat testis

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dc.contributor.authorÖzkaya, AK
dc.contributor.authorDilber, E
dc.contributor.authorGürgen, SG
dc.contributor.authorKutlu, Ö
dc.contributor.authorCansu, A
dc.contributor.authorGedik, Y
dc.date.accessioned2024-07-18T12:03:10Z
dc.date.available2024-07-18T12:03:10Z
dc.description.abstractAmiodarone is a potent agent used to treat tachyarrhythmias, which are especially refractory to other medications, in both adults and children. Although widely used as an antiarrhythmic drug, amiodarone causes many serious adverse effects that limit its use. This study investigated the possible morphological and apoptotic effects of amiodarone on rat testes. Amiodarone was administered to male Sprague-Dawley rats at doses of 20 or 200 mg/kg/day for 14 days. A histopathological examination of testicular tissue revealed the presence of inflammatory cells in the seminiferous tubule lumen together with swelling and vacuolization in the cytoplasm of some spermatogonia; these effects occured in a dose-dependent manner. Immunohistochemical staining showed evidence of apoptosis, including caspase-3, caspase-9, Bax and increased DNA fragmentation was detected via a terminal deoxynucleotidyl transferase dUTP nick-end labeling assay. In conclusion, the results show that chronic amiodarone treatment causes dose dependent degenerative and apoptotic effects on rat testes. (C) 2016 Elsevier GmbH. All rights reserved.
dc.identifier.issn0065-1281
dc.identifier.other1618-0372
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/8943
dc.language.isoEnglish
dc.publisherELSEVIER GMBH, URBAN & FISCHER VERLAG
dc.subjectACUTE MYOCARDIAL-INFARCTION
dc.subjectALVEOLAR EPITHELIAL-CELLS
dc.subjectANTIARRHYTHMIC-DRUG
dc.subjectAPOPTOSIS
dc.subjectPHOSPHOLIPIDOSIS
dc.subjectNEUROPATHY
dc.subjectTOXICITY
dc.subjectCHILDREN
dc.subjectNEUROTOXICITY
dc.subjectEPIDIDYMITIS
dc.titleEffects of chronic amiodarone treatment on rat testis
dc.typeArticle

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